Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.
about
Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimersSite-specific infrared probes of proteinsConstitutively active rhodopsin and retinal diseaseStabilized G protein binding site in the structure of constitutively active metarhodopsin-IIStructural approaches to understanding retinal proteins needed for visionChemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signallingEmerging targets in lipid-based therapyGenetically encoding a light switch in an ionotropic glutamate receptor reveals subunit-specific interfaces.Probing the effectiveness of spectroscopic reporter unnatural amino acids: a structural study.Expanding the genetic code of mammalian cells.Azido Homoalanine is a Useful Infrared Probe for Monitoring Local Electrostatistics and Sidechain Solvation in Proteins.Conformational equilibria of light-activated rhodopsin in nanodiscs.Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)Sequential rearrangement of interhelical networks upon rhodopsin activation in membranes: the Meta II(a) conformational substate.Ester carbonyl vibration as a sensitive probe of protein local electric field.Identifying functionally important conformational changes in proteins: activation of the yeast α-factor receptor Ste2pReprogramming the genetic code.Performance analysis of orthogonal pairs designed for an expanded eukaryotic genetic code.Cell surface display yields evolvable, clickable antibody fragments.Bioorthogonal chemical reporters for analyzing protein lipidation and lipid traffickingThe role of Cysteine 6.47 in class A GPCRsEnergy landscapes as a tool to integrate GPCR structure, dynamics, and function.Multiplex detection of functional G protein-coupled receptors harboring site-specifically modified unnatural amino acidsCurrent progress in Structure-Based Rational Drug Design marks a new mindset in drug discoveryCXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration.A pharmacological primer of biased agonismSite-Specific Spectroscopic Reporters of the Local Electric Field, Hydration, Structure, and Dynamics of Biomolecules.Activation mechanism of the β2-adrenergic receptor.Two-dimensional IR spectroscopy of protein dynamics using two vibrational labels: a site-specific genetically encoded unnatural amino acid and an active site ligandEnvironment Polarity in Proteins Mapped Noninvasively by FTIR SpectroscopyA platform for constructing, evaluating, and screening bioconjugates on the yeast surface.A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569.Azidoethoxyphenylalanine as a Vibrational Reporter and Click Chemistry Partner in ProteinsGenetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter.Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants.A constitutively activating mutation alters the dynamics and energetics of a key conformational change in a ligand-free G protein-coupled receptorRetinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation.Functionally biased signalling properties of 7TM receptors - opportunities for drug development for the ghrelin receptor.Genetically-encoded molecular probes to study G protein-coupled receptors.Microbial and animal rhodopsins: structures, functions, and molecular mechanisms.
P2860
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P2860
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.
@en
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.
@nl
type
label
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.
@en
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.
@nl
prefLabel
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.
@en
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.
@nl
P2093
P50
P356
P1433
P1476
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes
@en
P2093
Ekaterina Zaitseva
Gianluigi Caltabiano
Reiner Vogel
P2888
P304
P356
10.1038/NATURE08948
P407
P577
2010-04-11T00:00:00Z
P5875
P6179
1044901093