Structure of murine CTLA-4 and its role in modulating T cell responsiveness
about
Immunogenetics of Hashimoto's thyroiditisMolecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interactionTopological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonistsRole of CD28/B7 costimulation and IL-12/IL-10 interaction in the radiation-induced immune changesCrystal structure of human junctional adhesion molecule 1: Implications for reovirus bindingCrystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2Domain Metastability: A Molecular Basis for Immunoglobulin Deposition?Structural and Functional Studies of Igαβ and Its Assembly with the B Cell Antigen ReceptorRigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor TriggeringCrystal structure of a soluble CD28-Fab complexStructural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapyStructural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumabRemapping the type I diabetes association of the CTLA4 locusSignal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).Cellular mechanisms that cause suppressed gamma interferon secretion in endotoxin-tolerant mice.Sequence, structure, function, immunity: structural genomics of costimulation.T-cell regulation by CD28 and CTLA-4.The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell functionNegative feedback of T cell activation through inhibitory adapters and costimulatory receptors.T cell receptor signaling can directly enhance the avidity of CD28 ligand binding.Viewpoint: therapeutic implications of CTLA-4 compartmentalization.B7 family molecules as regulators of the maternal immune system in pregnancyPD-1/PD-L pathway and autoimmunity.Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activationCD28, costimulator or agonist receptor?Enhancement of gp120-specific immune responses by genetic vaccination with the human immunodeficiency virus type 1 envelope gene fused to the gene coding for soluble CTLA4.The molecular makeup and function of regulatory and effector synapses.At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapyCoinhibitory Pathways in the B7-CD28 Ligand-Receptor Family.Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxusCD4+ regulatory T cells require CTLA-4 for the maintenance of systemic toleranceSpontaneous colitis occurrence in transgenic mice with altered B7-mediated costimulation.An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies.Negative immune checkpoints on T lymphocytes and their relevance to cancer immunotherapy.CD28 Costimulation: From Mechanism to Therapy.Tumor-specific oncolytic adenoviruses expressing granulocyte macrophage colony-stimulating factor or anti-CTLA4 antibody for the treatment of cancers.CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.T-cell costimulation blockade in immunologic diseases: role of CD28 family members.Association between co-inhibitory molecule gene tagging single nucleotide polymorphisms and the risk of colorectal cancer in Chinese.Humanized mice as a model for aberrant responses in human T cell immunotherapy.
P2860
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P2860
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
@ast
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
@en
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
@nl
type
label
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
@ast
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
@en
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
@nl
prefLabel
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
@ast
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
@en
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
@nl
P2093
P3181
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P1476
Structure of murine CTLA-4 and its role in modulating T cell responsiveness
@en
P2093
P3181
P356
10.1126/SCIENCE.290.5492.816
P407
P577
2000-10-27T00:00:00Z