Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1.
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Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase.Structure of human O-GlcNAc transferase and its complex with a peptide substrateStructure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT)Hallmarks of glycosylation in cancerHijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic PhenotypesO-GlcNAcylation and the Metabolic Shift in High-Proliferating Cells: All the Evidence Suggests that Sugars Dictate the Flux of Lipid Biogenesis in Tumor ProcessesDysregulated metabolism contributes to oncogenesisCancer metabolism and elevated O-GlcNAc in oncogenic signalingFunctional O-GlcNAc modifications: implications in molecular regulation and pathophysiologySubstrate and product analogues as human O-GlcNAc transferase inhibitorsCrystal structure and functional characterization of a glucosamine-6-phosphate N-acetyltransferase from Arabidopsis thalianaGaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approachO-linked β-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cellsO-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases.Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cellsPreclinical evaluation of the novel monoclonal antibody H6-11 for prostate cancer imaging.O-GlcNAcylation: The Sweet Side of the Cancer.Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approachesdbOGAP - an integrated bioinformatics resource for protein O-GlcNAcylation.Boronic Acid-Modified Magnetic Fe3O4@mTiO2 Microspheres for Highly Sensitive and Selective Enrichment of N-Glycopeptides in Amniotic Fluid.O-GlcNAcylation stabilizes β-catenin through direct competition with phosphorylation at threonine 41.O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.O-GlcNAc-mediated interaction between VER2 and TaGRP2 elicits TaVRN1 mRNA accumulation during vernalization in winter wheatOGA heterozygosity suppresses intestinal tumorigenesis in Apc(min/+) mice.Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modificationO-GlcNAc signaling: a metabolic link between diabetes and cancer?A two-way street: reciprocal regulation of metabolism and signalling.Long non-coding RNAs differentially expressed between normal versus primary breast tumor tissues disclose converse changes to breast cancer-related protein-coding genes.Phosphorylation of transglutaminase 2 (TG2) at serine-216 has a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTENSystemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma.Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathwaysO-GlcNAc signaling in cancer metabolism and epigeneticsDevelopment of inhibitors as research tools for carbohydrate-processing enzymes.Aberrant O-GlcNAcylated Proteins: New Perspectives in Breast and Colorectal Cancer.X marks the spot: does it matter that O-GlcNAc transferase is an X-linked gene?N-linked glycosylation supports cross-talk between receptor tyrosine kinases and androgen receptor.Proteomic approaches for site-specific O-GlcNAcylation analysis.Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1Hypoxia/HIF1α induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2Proteomics profiling identify CAPS as a potential predictive marker of tamoxifen resistance in estrogen receptor positive breast cancer.
P2860
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P2860
Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Nutrient sensor O-GlcNAc trans ...... ic transcription factor FoxM1.
@en
Nutrient sensor O-GlcNAc trans ...... ic transcription factor FoxM1.
@nl
type
label
Nutrient sensor O-GlcNAc trans ...... ic transcription factor FoxM1.
@en
Nutrient sensor O-GlcNAc trans ...... ic transcription factor FoxM1.
@nl
prefLabel
Nutrient sensor O-GlcNAc trans ...... ic transcription factor FoxM1.
@en
Nutrient sensor O-GlcNAc trans ...... ic transcription factor FoxM1.
@nl
P2093
P356
P1433
P1476
Nutrient sensor O-GlcNAc trans ...... nic transcription factor FoxM1
@en
P2093
K S Shahriari
K Vosseller
M J Reginato
S A Caldwell
S R Jackson
P2888
P304
P356
10.1038/ONC.2010.41
P407
P50
P577
2010-03-01T00:00:00Z