Genetic analysis of beta1 integrin "activation motifs" in mice.
about
Quantitative proteomics identifies a Dab2/integrin module regulating cell migrationKindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effectsIntegrin cytoplasmic tail interactionsThe talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clusteringAn integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin bindingThe structure of an integrin/talin complex reveals the basis of inside-out signal transduction.Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinityKindlin-2 controls bidirectional signaling of integrinsIntegrin β3 crosstalk with VEGFR accommodating tyrosine phosphorylation as a regulatory switchGenetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates alpha(4) integrinsOsteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition.Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration.Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease.Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli.Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction.Beta1 integrin-mediated adhesion signalling is essential for epidermal progenitor cell expansion.New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering.The final steps of integrin activation: the end gameZasp regulates integrin activation.Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.The tail of integrin activation.Analysis of conserved residues in the betapat-3 cytoplasmic tail reveals important functions of integrin in multiple tissues.Contributions of the integrin β1 tail to cell adhesive forces.Beta1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation.The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation.NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry.Role of integrins in the assembly and function of hensin in intercalated cellsRegulation of integrin activity and signallingThe ins and outs of leukocyte integrin signaling.Focal adhesion complex proteins in epidermis and squamous cell carcinoma.Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.Kindling the flame of integrin activation and function with kindlinsImplications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function.Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation.Late endosomal and lysosomal trafficking during integrin-mediated cell migration and invasion: cell matrix receptors are trafficked through the late endosomal pathway in a way that dictates how cells migrate.β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins.Talin - the master of integrin adhesions.The RGD motif in fibronectin is essential for development but dispensable for fibril assembly.
P2860
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P2860
Genetic analysis of beta1 integrin "activation motifs" in mice.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Genetic analysis of beta1 integrin "activation motifs" in mice.
@en
Genetic analysis of beta1 integrin "activation motifs" in mice.
@nl
type
label
Genetic analysis of beta1 integrin "activation motifs" in mice.
@en
Genetic analysis of beta1 integrin "activation motifs" in mice.
@nl
prefLabel
Genetic analysis of beta1 integrin "activation motifs" in mice.
@en
Genetic analysis of beta1 integrin "activation motifs" in mice.
@nl
P2860
P50
P356
P1476
Genetic analysis of beta1 integrin "activation motifs" in mice.
@en
P2093
Aleksandra Czuchra
Hannelore Meyer
P2860
P304
P356
10.1083/JCB.200604060
P407
P577
2006-09-05T00:00:00Z