Role of Mdm4 in drug sensitivity of breast cancer cells. - Wikidata - awgldk - TriplyDB

Role of Mdm4 in drug sensitivity of breast cancer cells.

Role of Mdm4 in drug sensitivity of breast cancer cells.

http://www.wikidata.org/entity/Q39742276

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Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization Functional activation of mutant p53V172F by platinum analogs in cisplatin-resistant human tumor cells is dependent on serine-20 phosphorylation MDM2, MDMX and p53 in oncogenesis and cancer therapy Prediction of disease genes using tissue-specified gene-gene network Wild type p53 reactivation: from lab bench to clinic.The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization.High levels of Hdmx promote cell growth in a subset of uveal melanomas.Targeting Mdmx to treat breast cancers with wild-type p53.Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth.Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer.Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator MDM4 is a key therapeutic target in cutaneous melanoma.The Zn-finger domain of MdmX suppresses cancer progression by promoting genome stability in p53-mutant cells.Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53.The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious Functions of MDMX in the modulation of the p53-response.Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX.Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53.Chk2 mediates RITA-induced apoptosis Synergistic growth inhibition based on small-molecule p53 activation as treatment for intraocular melanoma.HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.A small molecule drug promoting miRNA processing induces alternative splicing of MdmX transcript and rescues p53 activity in human cancer cells overexpressing MdmX protein Wild-type p53 inhibits pro-invasive properties of TGF-β3 in breast cancer, in part through regulation of EPHB2, a new TGF-β target gene.Mdmx promotes genomic instability independent of p53 and Mdm2.Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE.Alkynylation of Bio-Based 5-Hydroxymethylfurfural to Connect Biomass Processing with Conjugated Polymers and Furanic Pharmaceuticals.

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P2860

Role of Mdm4 in drug sensitivity of breast cancer cells.

http://www.wikidata.org/entity/Q39742276

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

2010年學術文章

@zh

2010年學術文章

@zh-hant

name

Role of Mdm4 in drug sensitivity of breast cancer cells.

@en

Role of Mdm4 in drug sensitivity of breast cancer cells.

@nl

type

label

Role of Mdm4 in drug sensitivity of breast cancer cells.

@en

Role of Mdm4 in drug sensitivity of breast cancer cells.

@nl

prefLabel

Role of Mdm4 in drug sensitivity of breast cancer cells.

@en

Role of Mdm4 in drug sensitivity of breast cancer cells.

@nl

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Role of Mdm4 in drug sensitivity of breast cancer cells.

@en

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A F A S Teunisse

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A G Jochemsen

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K Lodder

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M J W E Rabelink

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M Schutte

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S Lam

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P2860

Isolation and identification of the human homolog of a new p53-binding protein, Mdmx

Mdm2 promotes the rapid degradation of p53

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Regulation of p53 stability by Mdm2

A system for stable expression of short interfering RNAs in mammalian cells

Hdmx modulates the outcome of p53 activation in human tumor cells

ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation

Amplification of a gene encoding a p53-associated protein in human sarcomas

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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2415-2426

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scholarly article

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10.1038/ONC.2009.522

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16

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29

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20140020

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