An electrostatic potassium channel opener targeting the final voltage sensor transition.
about
Polyunsaturated fatty acid supplementation for drug-resistant epilepsyPolyunsaturated fatty acid supplementation for drug-resistant epilepsyVoltage gated ion channel function: gating, conduction, and the role of water and protonsMechanosensitive gating of Kv channelsIn-Depth Study of the Interaction, Sensitivity, and Gating Modulation by PUFAs on K+ Channels; Interaction and New TargetsFatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel FunctionRegulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitabilityMolecular determinants of Hv1 proton channel inhibition by guanidine derivatives.Dampening of hyperexcitability in CA1 pyramidal neurons by polyunsaturated fatty acids acting on voltage-gated ion channelsReduced sialylation impacts ventricular repolarization by modulating specific K+ channel isoforms distinctly.Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channelElectronic polymers in lipid membranes.The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage-Gated Potassium ChannelTracking a complete voltage-sensor cycle with metal-ion bridges.Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening.A limited 4 Å radial displacement of the S4-S5 linker is sufficient for internal gate closing in Kv channels.The conserved phenylalanine in the K+ channel voltage-sensor domain creates a barrier with unidirectional effects.Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channelsReciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation.Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels.Drug-induced ion channel opening tuned by the voltage sensor charge profile.Mechanism of electromechanical coupling in voltage-gated potassium channels.Can selectivity be functionally modulated in ion channels?Isopimaric acid - a multi-targeting ion channel modulator reducing excitability and arrhythmicity in a spontaneously beating mouse atrial cell line.Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations.Extracellular Linkers Completely Transplant the Voltage Dependence from Kv1.2 Ion Channels to Kv2.1.Tetraphenylporphyrin derivative specifically blocks members of the voltage-gated potassium channel subfamily Kv1.Do lipids show state-dependent affinity to the voltage-gated potassium channel KvAP?Modulation of plant TPC channels by polyunsaturated fatty acids.Polyunsaturated fatty acids inhibit Kv1.4 by interacting with positively charged extracellular pore residuesA drug pocket at the lipid bilayer-potassium channel interface.Arachidonic acid closes innexin/pannexin channels and thereby inhibits microglia cell movement to a nerve injury.Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid.Rapid adaptation of Rhodococcus erythropolis cells to salt stress by synthesizing polyunsaturated fatty acids
P2860
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P2860
An electrostatic potassium channel opener targeting the final voltage sensor transition.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
An electrostatic potassium channel opener targeting the final voltage sensor transition.
@en
An electrostatic potassium channel opener targeting the final voltage sensor transition.
@nl
type
label
An electrostatic potassium channel opener targeting the final voltage sensor transition.
@en
An electrostatic potassium channel opener targeting the final voltage sensor transition.
@nl
prefLabel
An electrostatic potassium channel opener targeting the final voltage sensor transition.
@en
An electrostatic potassium channel opener targeting the final voltage sensor transition.
@nl
P2860
P356
P1476
An electrostatic potassium channel opener targeting the final voltage sensor transition.
@en
P2860
P304
P356
10.1085/JGP.201110599
P577
2011-06-01T00:00:00Z