Investigating the structural basis of purine specificity in the structures of MS2 coat protein RNA translational operator hairpinsNucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerizationMore-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding moleculesCrystal structures of MS2 capsids with mutations in the subunit FG loopCrystal structures of MS2 coat protein mutants in complex with wild-type RNA operator fragmentsCrystal structures of a series of RNA aptamers complexed to the same protein targetCrystallographic studies of RNA hairpins in complexes with recombinant MS2 capsids: implications for binding requirements.Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric poreProbing the kinetics of formation of the bacteriophage MS2 translational operator complex: identification of a protein conformer unable to bind RNA.All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding.High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors.An RNA aptamer provides a novel approach for the induction of apoptosis by targeting the HPV16 E7 oncoprotein.Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteinsEmploying transposon mutagenesis to investigate foot-and-mouth disease virus replication.The Subcellular Localisation of the Human Papillomavirus (HPV) 16 E7 Protein in Cervical Cancer Cells and Its Perturbation by RNA Aptamers.YIP1 family member 4 (YIPF4) is a novel cellular binding partner of the papillomavirus E5 proteinsPotent antiviral agents fail to elicit genetically-stable resistance mutations in either enterovirus 71 or Coxsackievirus A16.Insights into virus capsid assembly from non-covalent mass spectrometry.Increasing Type 1 Poliovirus Capsid Stability by Thermal Selection.Effects of single nucleotide changes on the binding and activity of RNA aptamers to human papillomavirus 16 E7 oncoprotein.Foot-and-mouth disease virus genome replication is unaffected by inhibition of type III phosphatidylinositol-4-kinases.RNA-induced conformational changes in a viral coat protein studied by hydrogen/deuterium exchange mass spectrometry.Selection and characterization of RNA aptamers to the RNA-dependent RNA polymerase from foot-and-mouth disease virus.Viral genomic single-stranded RNA directs the pathway toward a T=3 capsid.Determining the topology of virus assembly intermediates using ion mobility spectrometry-mass spectrometryInhibition of the foot-and-mouth disease virus subgenomic replicon by RNA aptamers.An RNA Aptamer Targets the PDZ-Binding Motif of the HPV16 E6 Oncoprotein.Formation of higher-order foot-and-mouth disease virus 3D(pol) complexes is dependent on elongation activityBoth cis and trans Activities of Foot-and-Mouth Disease Virus 3D Polymerase Are Essential for Viral RNA Replication.Engineering thermal stability in RNA phage capsids via disulphide bonds.Probing sequence-specific RNA recognition by the bacteriophage MS2 coat protein.FMDV replicons encoding green fluorescent protein are replication competent.Assembly Pathway of Hepatitis B Core Virus-like Particles from Genetically Fused Dimers.Using ion mobility spectrometry-mass spectrometry to decipher the conformational and assembly characteristics of the hepatitis B capsid protein.Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways.The crystal structure of a high affinity RNA stem-loop complexed with the bacteriophage MS2 capsid: further challenges in the modeling of ligand-RNA interactions.Probing bunyavirus N protein oligomerisation using mass spectrometry.Affinity of molecular interactions in the bacteriophage phi29 DNA packaging motor.Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner.IL-17A RNA aptamer: possible therapeutic potential in some cells, more than we bargained for in others?
P50
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P50
description
Professor of Molecular Virology at the University of Leeds
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola J Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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Nicola Stonehouse
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1989-01-01T00:00:00Z
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