Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.
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Functions of Ubiquitin and SUMO in DNA Replication and Replication StressRegulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteinsArsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligaseRole of Pirh2 in mediating the regulation of p53 and c-Myc.The unusual UBZ domain of Saccharomyces cerevisiae polymerase ηTranslesion DNA polymerasesIdentification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin.The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation.Human Pirh2 is a novel inhibitor of prototype foamy virus replication.Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1.DNA polymerase η is regulated by poly(rC)-binding protein 1 via mRNA stabilityArsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of ΔNp63 protein.A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forksp53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA.TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η.E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells.DNA polymerase eta and chemotherapeutic agents.A novel oncoprotein Pirh2: rising from the shadow of MDM2.Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy.Translesion DNA synthesis and mutagenesis in eukaryotesREV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1.Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis.Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases.The homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1.Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases.Cdk9 phosphorylates Pirh2 protein and prevents degradation of p53 protein.Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63.DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation.The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover.Translesion Synthesis of 2'-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases.The transcription factor MEF/Elf4 is dually modulated by p53-MDM2 axis and MEF-MDM2 autoregulatory mechanism.Phosphorylation regulates human polη stability and damage bypass throughout the cell cycle.RCHY1 binds POLHRegulation of Mammalian DNA Replication via the Ubiquitin-Proteasome System.
P2860
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P2860
Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.
@en
Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.
@nl
type
label
Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.
@en
Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.
@nl
prefLabel
Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.
@en
Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation.
@nl
P2860
P356
P1476
Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation
@en
P2093
Xinbin Chen
Yong-Sam Jung
P2860
P304
P356
10.1128/MCB.01198-09
P407
P50
P577
2009-12-14T00:00:00Z