mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling. - Wikidata - awgldk - TriplyDB

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

http://www.wikidata.org/entity/Q39765614

about

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy The role and regulation of mTOR in T-lymphocyte function Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin The expanding role of mTOR in cancer cell growth and proliferation Gammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic disease Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives mTOR inhibitors in cancer therapy From Nutrient to MicroRNA: a Novel Insight into Cell Signaling Involved in Skeletal Muscle Development and Disease mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR miRNA Alterations Modify Kinase Activation In The IGF-1 Pathway And Correlate With Colorectal Cancer Stage And Progression In Patients Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease PI3K at the crossroads of tumor angiogenesis signaling pathways S6K1 and 4E-BP1 are independent regulated and control cellular growth in bladder cancer Suppression of AKT anti-apoptotic signaling by a novel drug candidate results in growth arrest and apoptosis of hepatocellular carcinoma cells Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-кB cascade in astrocytic oxygen-glucose deprivation Gab2 phosphorylation by RSK inhibits Shp2 recruitment and cell motility mTORC1 and JNK coordinate phosphorylation of the p70S6K1 autoinhibitory domain in skeletal muscle following functional overloading.Foxo transcription factors control regulatory T cell development and function Formal Modeling of mTOR Associated Biological Regulatory Network Reveals Novel Therapeutic Strategy for the Treatment of Cancer.mTORC2 in the center of cancer metabolic reprogramming Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the "Yin" and "Yang" effects of mammalian target of rapamycin complex 1 (mTORC1) and mTORC2.Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt.Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction.Liver clock protein BMAL1 promotes de novo lipogenesis through insulin-mTORC2-AKT signaling mTOR signaling for biological control and cancer.Sestrins orchestrate cellular metabolism to attenuate aging.microRNA regulation of mammalian target of rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity.PARP-1 modulation of mTOR signaling in response to a DNA alkylating agent.Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins.DEPTOR is a stemness factor that regulates pluripotency of embryonic stem cells Holothurian glycosaminoglycan inhibits metastasis and thrombosis via targeting of nuclear factor-κB/tissue factor/Factor Xa pathway in melanoma B16F10 cells Growing knowledge of the mTOR signaling network.Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation.Rheb1 is required for mTORC1 and myelination in postnatal brain development Rapamycin protection of livers from ischemia and reperfusion injury is dependent on both autophagy induction and mammalian target of rapamycin complex 2-Akt activation.

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P2860

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

http://www.wikidata.org/entity/Q39765614

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

@zh-hans

2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

@yue

2009年學術文章

@zh

2009年學術文章

@zh-hant

name

mTORC1-activated S6K1 phosphor ...... nd regulates mTORC2 signaling.

@en

mTORC1-activated S6K1 phosphor ...... nd regulates mTORC2 signaling.

@nl

type

label

mTORC1-activated S6K1 phosphor ...... nd regulates mTORC2 signaling.

@en

mTORC1-activated S6K1 phosphor ...... nd regulates mTORC2 signaling.

@nl

prefLabel

mTORC1-activated S6K1 phosphor ...... nd regulates mTORC2 signaling.

@en

mTORC1-activated S6K1 phosphor ...... nd regulates mTORC2 signaling.

@nl

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Molecular and Cellular Biology

P1476

mTORC1-activated S6K1 phosphor ...... nd regulates mTORC2 signaling.

@en

P2093

Audrey Carriere

http://www.w3.org/2001/XMLSchema#string

Julie Moreau

http://www.w3.org/2001/XMLSchema#string

Louis-Andre Julien

http://www.w3.org/2001/XMLSchema#string

P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

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908-921

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scholarly article

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10.1128/MCB.00601-09

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4

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30

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Philippe P. Roux

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2009-12-07T00:00:00Z

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19995915

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phosphorylation

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2815569

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