Ca(2+) puffs originate from preestablished stable clusters of inositol trisphosphate receptors
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Differential distribution, clustering, and lateral diffusion of subtypes of the inositol 1,4,5-trisphosphate receptorMean field strategies induce unrealistic non-linearities in calcium puffsEndoplasmic reticulum-mediated signalling in cellular microdomains.Recording single-channel activity of inositol trisphosphate receptors in intact cells with a microscope, not a patch clamp.A comparison of fluorescent Ca²⁺ indicators for imaging local Ca²⁺ signals in cultured cells.Hindered cytoplasmic diffusion of inositol trisphosphate restricts its cellular range of action.Superresolution localization of single functional IP3R channels utilizing Ca2+ flux as a readoutSingle-molecule tracking of inositol trisphosphate receptors reveals different motilities and distributionsEndoplasmic reticulum remodeling tunes IP₃-dependent Ca²+ release sensitivity.An algorithm for automated detection, localization and measurement of local calcium signals from camera-based imagingCooperative and stochastic calcium releases from multiple calcium puff sites generate calcium microdomains in intact Hela cells.Multi-scale data-driven modeling and observation of calcium puffs.Inositol (1,4,5)-trisphosphate receptor microarchitecture shapes Ca2+ puff kineticsCalcium oscillations.Active generation and propagation of Ca2+ signals within tunneling membrane nanotubesInositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view.The probability of triggering calcium puffs is linearly related to the number of inositol trisphosphate receptors in a cluster.Temperature dependence of IP3-mediated local and global Ca2+ signals.Spatiotemporal organization of Ca dynamics: a modeling-based approach.Dynamic clustering of IP3 receptors by IP3.Imaging large cohorts of single ion channels and their activity.Ca2+ Microdomains in T-LymphocytesSeeing is believing! Imaging Ca2+-signalling events in living cells.IP3 receptors: Take four IP3 to open.Intracellular calcium signals display an avalanche-like behavior over multiple lengthscales.Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP3 Receptors in the Induction of Hyperalgesic Priming.Actin-based confinement of calcium responses during Shigella invasion.Ca2+ signals initiate at immobile IP3 receptors adjacent to ER-plasma membrane junctions.Endogenous signalling pathways and caged IP3 evoke Ca2+ puffs at the same abundant immobile intracellular sites.Synaptic neuron-astrocyte communication is supported by an order of magnitude analysis of inositol tris-phosphate diffusion at the nanoscale in a model of peri-synaptic astrocyte projection.[Calcium signaling in T lymphocytes].All three IP receptor subtypes generate Ca puffs, the universal building blocks of IP-evoked Ca signalsDisentangling astroglial physiology with a realistic cell model in silico
P2860
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P2860
Ca(2+) puffs originate from preestablished stable clusters of inositol trisphosphate receptors
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
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2009年学术文章
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2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
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2009年學術文章
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name
Ca(2+) puffs originate from pr ...... ositol trisphosphate receptors
@en
type
label
Ca(2+) puffs originate from pr ...... ositol trisphosphate receptors
@en
prefLabel
Ca(2+) puffs originate from pr ...... ositol trisphosphate receptors
@en
P2093
P2860
P1433
P1476
Ca(2+) puffs originate from pr ...... ositol trisphosphate receptors
@en
P2093
Ian F Smith
Ian Parker
Jianwei Shuai
Steven M Wiltgen
P2860
P356
10.1126/SCISIGNAL.2000466
P577
2009-11-24T00:00:00Z