Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes.
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Addressing unmet medical needs in type 2 diabetes: a narrative review of drugs under developmentDiscovery of DS-1558: A Potent and Orally Bioavailable GPR40 AgonistGPR142 Agonists Stimulate Glucose-Dependent Insulin Secretion via Gq-Dependent SignalingGPR142 Controls Tryptophan-Induced Insulin and Incretin Hormone Secretion to Improve Glucose MetabolismDiscovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.Insights into unbound-bound states of GPR142 receptor in a membrane-aqueous system using molecular dynamics simulations.GPR142 prompts glucagon-like Peptide-1 release from islets to improve β cell function.Differential role of GPR142 in tryptophan-mediated enhancement of insulin secretion in obese and lean mice.
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Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes.
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2013 nî lūn-bûn
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2013年の論文
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Potent and Orally Bioavailable ...... Treatment of Type 2 Diabetes.
@en
Potent and Orally Bioavailable ...... Treatment of Type 2 Diabetes.
@nl
type
label
Potent and Orally Bioavailable ...... Treatment of Type 2 Diabetes.
@en
Potent and Orally Bioavailable ...... Treatment of Type 2 Diabetes.
@nl
prefLabel
Potent and Orally Bioavailable ...... Treatment of Type 2 Diabetes.
@en
Potent and Orally Bioavailable ...... Treatment of Type 2 Diabetes.
@nl
P2093
P2860
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Potent and Orally Bioavailable ...... e Treatment of Type 2 Diabetes
@en
P2093
Alykhan Motani
Futoshi Nara
Jeff D Reagan
Julio Medina
Masanori Izumi
Michiko Murakoshi
P2860
P304
P356
10.1021/ML400186Z
P50
P577
2013-06-17T00:00:00Z