In vivo antimalarial activities of mono- and bis quaternary ammonium salts interfering with Plasmodium phospholipid metabolism
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Inhibition of Plasmodium falciparum choline kinase by hexadecyltrimethylammonium bromide: a possible antimalarial mechanismCholine analogues in malaria chemotherapyComparison of the cellular and biochemical properties of Plasmodium falciparum choline and ethanolamine kinasesPlasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP-choline analog selected from a virtual screeningA systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparumIdentification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay.Safety and efficacy of the choline analogue SAR97276 for malaria treatment: results of two phase 2, open-label, multicenter trials in African patients.Symmetrical choline-derived dications display strong anti-kinetoplastid activity.Pharmacological properties of a new antimalarial bisthiazolium salt, T3, and a corresponding prodrug, TE3.Potent antihematozoan activity of novel bisthiazolium drug T16: evidence for inhibition of phosphatidylcholine metabolism in erythrocytes infected with Babesia and Plasmodium spp.Potent inhibitors of Plasmodium phospholipid metabolism with a broad spectrum of in vitro antimalarial activities.Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytesAntiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives.Prodrugs of bisthiazolium salts are orally potent antimalarialsNovel antimalarial drug targets: hope for new antimalarial drugs.Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions?Reliability of antimalarial sensitivity tests depends on drug mechanisms of action.Unraveling the mode of action of the antimalarial choline analog G25 in Plasmodium falciparum and Saccharomyces cerevisiae.New insight into the mechanism of accumulation and intraerythrocytic compartmentation of albitiazolium, a new type of antimalarial.Characterization of the lipid-binding domain of the Plasmodium falciparum CTP:phosphocholine cytidylyltransferase through synthetic-peptide studies.Antimicrobial and antiplasmodial activities of a quaternary compound from Ritchiea capparoides var. longipedicellata.Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidateDevelopment of the first oral bioprecursors of bis-alkylguanidine antimalarial drugs.Evaluation of bis-alkylamidoxime O-alkylsulfonates as orally available antimalarials.Hydrolysis kinetics and QSAR investigation of soft antimicrobial agents.Synthesis and in vitro antimicrobial evaluation of new N-heterocyclic diquaternary pyridinium compounds.
P2860
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P2860
In vivo antimalarial activities of mono- and bis quaternary ammonium salts interfering with Plasmodium phospholipid metabolism
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
In vivo antimalarial activitie ...... modium phospholipid metabolism
@en
In vivo antimalarial activitie ...... odium phospholipid metabolism.
@nl
type
label
In vivo antimalarial activitie ...... modium phospholipid metabolism
@en
In vivo antimalarial activitie ...... odium phospholipid metabolism.
@nl
prefLabel
In vivo antimalarial activitie ...... modium phospholipid metabolism
@en
In vivo antimalarial activitie ...... odium phospholipid metabolism.
@nl
P2093
P2860
P1476
In vivo antimalarial activitie ...... modium phospholipid metabolism
@en
P2093
Anne Bonhoure
Henri J Vial
Michèle Calas
Serge Herbute
P2860
P304
P356
10.1128/AAC.47.8.2598-2605.2003
P407
P577
2003-08-01T00:00:00Z