2,4-Diamino-5-(2'-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition.

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Crystal Structures of Candida albicans Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal the Flexibility of Active Site Loop Residues Critical for Ligand Potency and Selectivity

P2860

Q27670663-A57E50D9-3E65-4560-9D43-DA9B300D6D5B

P2860

2,4-Diamino-5-(2'-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition.

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http://www.wikidata.org/entity/Q39807158

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2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

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2010年學術文章

@yue

2010年學術文章

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2010年學術文章

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2,4-Diamino-5-(2'-arylpropargy ...... rofolate reductase inhibition.

@en

2,4-Diamino-5-(2'-arylpropargy ...... rofolate reductase inhibition.

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type

Item

label

2,4-Diamino-5-(2'-arylpropargy ...... rofolate reductase inhibition.

@en

2,4-Diamino-5-(2'-arylpropargy ...... rofolate reductase inhibition.

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prefLabel

2,4-Diamino-5-(2'-arylpropargy ...... rofolate reductase inhibition.

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2,4-Diamino-5-(2'-arylpropargy ...... rofolate reductase inhibition.

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P1476

2,4-Diamino-5-(2'-arylpropargy ...... rofolate reductase inhibition.

@en

P2093

Amy C Anderson

http://www.w3.org/2001/XMLSchema#string

Janet L Paulsen

http://www.w3.org/2001/XMLSchema#string

Oztekin Algul

http://www.w3.org/2001/XMLSchema#string

P2860

Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution

Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase

Structure-Guided Development of Efficacious Antifungal Agents Targeting Candida glabrata Dihydrofolate Reductase

Synthetic and Crystallographic Studies of a New Inhibitor Series Targeting Bacillus anthracis Dihydrofolate Reductase

Probing the Active Site ofCandida glabrataDihydrofolate Reductase with High Resolution Crystal Structures and the Synthesis of New Inhibitors

Crystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim Resistance

Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3- d ]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents

Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers

Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523

Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine

P304

608-613

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scholarly article

P356

10.1016/J.JMGM.2010.11.004

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http://www.w3.org/2001/XMLSchema#string

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http://www.w3.org/2001/XMLSchema#string

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2010-11-11T00:00:00Z

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49672368

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21146434

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3073677

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2,4-Diamino-5-(2'-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition.

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P2860

P2860

2,4-Diamino-5-(2'-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition.

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