The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration.
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Link protein N-terminal peptide and fullerol promote matrix production and decrease degradation enzymes in rabbit annulus cells.The challenge and advancement of annulus fibrosus tissue engineering.A Histopathological Scheme for the Quantitative Scoring of Intervertebral Disc Degeneration and the Therapeutic Utility of Adult Mesenchymal Stem Cells for Intervertebral Disc Regeneration.Novel immortal human cell lines reveal subpopulations in the nucleus pulposus.Fabrication and properties of acellular porcine anulus fibrosus for tissue engineering in spine surgery.Needle puncture in rabbit functional spinal units alters rotational biomechanics.Population average T2 MRI maps reveal quantitative regional transformations in the degenerating rabbit intervertebral disc that vary by lumbar level.Degenerative grade affects the responses of human nucleus pulposus cells to link-N, CTGF, and TGFβ3.Elevated interleukin-6 expression levels are associated with intervertebral disc degeneration.Effect of autologous platelet-rich plasma-releasate on intervertebral disc degeneration in the rabbit anular puncture model: a preclinical study.Cell signaling pathways related to pain receptors in the degenerated disk.Reconstruction of an in vitro niche for the transition from intervertebral disc development to nucleus pulposus regeneration.Molecular therapy for disk degeneration and pain.Biologic treatment of mild and moderate intervertebral disc degeneration.Relevance of bioreactors and whole tissue cultures for the translation of new therapies to humans.Strategies in regenerative medicine for intervertebral disc repair using mesenchymal stem cells and bioscaffolds.Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB.IL-1β promotes ADAMTS enzyme-mediated aggrecan degradation through NF-κB in human intervertebral disc.Optimized decellularization protocol including α-Gal epitope reduction for fabrication of an acellular porcine annulus fibrosus scaffold.The effect of Link N on differentiation of human bone marrow-derived mesenchymal stem cells.Link N and mesenchymal stem cells can induce regeneration of the early degenerate intervertebral disc.Normal and degenerated rabbit nucleus pulposus cells in in vitro cultures: A biological comparison.Ghrelin protects against nucleus pulposus degeneration through inhibition of NF-κB signaling pathway and activation of Akt signaling pathway.Link-N: The missing link towards intervertebral disc repair is species-specific.ISSLS PRIZE IN BASIC SCIENCE 2018: Growth differentiation factor-6 attenuated pro-inflammatory molecular changes in the rabbit anular-puncture model and degenerated disc-induced pain generation in the rat xenograft radiculopathy model.Glutathione protects human nucleus pulposus cells from cell apoptosis and inhibition of matrix synthesis.Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside.Link N is cleaved by human annulus fibrosus cells generating a fragment with retained biological activityShort Link N promotes disc repair in a rabbit model of disc degeneration
P2860
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P2860
The efficacy of Link N as a mediator of repair in a rabbit model of intervertebral disc degeneration.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
The efficacy of Link N as a me ...... ervertebral disc degeneration.
@en
The efficacy of Link N as a me ...... ervertebral disc degeneration.
@nl
type
label
The efficacy of Link N as a me ...... ervertebral disc degeneration.
@en
The efficacy of Link N as a me ...... ervertebral disc degeneration.
@nl
prefLabel
The efficacy of Link N as a me ...... ervertebral disc degeneration.
@en
The efficacy of Link N as a me ...... ervertebral disc degeneration.
@nl
P2093
P2860
P356
P1476
The efficacy of Link N as a me ...... ervertebral disc degeneration.
@en
P2093
Aseem Hemmad
Fackson Mwale
John Antoniou
Koichi Masuda
Laura M Epure
Peter J Roughley
Rajeswari Pichika
Tomoaki Yoshikawa
P2860
P2888
P356
10.1186/AR3423
P577
2011-07-25T00:00:00Z
P5875
P6179
1007606965