Mechanisms of carcinogenesis induced by alkylating agents.
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Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferaseHigh-resolution structure of a mutagenic lesion in DNADNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugateNormal human breast xenografts activate N-nitrosodimethylamine: identification of potential target cells for an environmental nitrosamineTherapy-related myeloid neoplasms: pathobiology and clinical characteristicsIsolation and partial characterisation of a Chinese hamster O6-alkylguanine-DNA alkyltransferase cDNA.Development of a novel site-specific mutagenesis assay using MALDI-ToF MS (SSMA-MS).Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks.Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk studyChemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electrochemical detectionDepletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases.Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.Characterization of revertants of unc-93(e1500) in Caenorhabditis elegans induced by N-ethyl-N-nitrosourea.Relationship between schistosomiasis and bladder cancerMus308 processes oxygen and nitrogen ethylation DNA damage in germ cells of Drosophila.DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.High- to low-dose extrapolation: critical determinants involved in the dose response of carcinogenic substances.Identification of a 59 bp enhancer located at the first exon/intron boundary of the human O6-methylguanine DNA methyltransferase gene.In vitro DNA replication implicates O2-ethyldeoxythymidine in transversion mutagenesis by ethylating agents.The role of mutagenic metal ions in mediating in vitro mispairing by alkylpyrimidines.C4-methyldeoxythymidine replacing deoxythymidine in poly[d(A-T)] renders the polymer resistant to the 3'----5' exonuclease activity of the Klenow and T4 DNA polymerasesAgricultural pesticide use and adenocarcinomas of the stomach and oesophagus.Frailty in childhood cancer survivors.O6-methylguanine inhibits the binding of transcription factors to DNA.Purification to apparent homogeneity and partial amino acid sequence of rat liver O6-alkylguanine-DNA-alkyltransferaseExpression of a human O6-alkylguanine-DNA-alkyltransferase cDNA in human cells and transgenic mice.32P-post-labelling analysis of DNA adducts formed in the upper gastrointestinal tissue of mice fed bracken extract or bracken sporesCharacterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli.Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection.O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis.Inducibility of the DNA repair gene encoding O6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments.Gastrointestinal and hepatotoxicity assessment of an anticancer extract from muricid molluscs.Comparison of 2,2-bis(bromomethyl)-1,3-propanediol induced genotoxicity in UROtsa cells and primary rat hepatocytes: relevance of metabolism and oxidative stressReduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene.Lack of the DNA repair protein O6-methylguanine-DNA methyltransferase in histologically normal brain adjacent to primary human brain tumors.A novel DNA damage recognition protein in Schizosaccharomyces pombe.Increased susceptibility to streptozotocin-induced beta-cell apoptosis and delayed autoimmune diabetes in alkylpurine-DNA-N-glycosylase-deficient mice.Small, Acid-Soluble Spore Proteins of the alpha/beta Type Do Not Protect the DNA in Bacillus subtilis Spores against Base Alkylation
P2860
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P2860
Mechanisms of carcinogenesis induced by alkylating agents.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
Mechanisms of carcinogenesis induced by alkylating agents.
@en
Mechanisms of carcinogenesis induced by alkylating agents.
@nl
type
label
Mechanisms of carcinogenesis induced by alkylating agents.
@en
Mechanisms of carcinogenesis induced by alkylating agents.
@nl
prefLabel
Mechanisms of carcinogenesis induced by alkylating agents.
@en
Mechanisms of carcinogenesis induced by alkylating agents.
@nl
P2093
P1476
Mechanisms of carcinogenesis induced by alkylating agents.
@en
P2093
G P Margison
P J O'Connor
R Saffhill
P304
P356
10.1016/0304-419X(85)90009-5
P577
1985-12-01T00:00:00Z