Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteasomal degradation.
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Pharmacology and Clinical Drug Candidates in Redox MedicineReactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical IndicationsStructure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.Oxidative stress associated with middle aging leads to sympathetic hyperactivity and downregulation of soluble guanylyl cyclase in corpus cavernosumFluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cellsThe amino-terminus of nitric oxide sensitive guanylyl cyclase α₁ does not affect dimerization but influences subcellular localizationChronic Activation of Heme Free Guanylate Cyclase Leads to Renal Protection in Dahl Salt-Sensitive Rats.Is Nostoc H-NOX a NO sensor or redox switch?The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies.Nitric oxide and heat shock protein 90 activate soluble guanylate cyclase by driving rapid change in its subunit interactions and heme content.Roles for soluble guanylate cyclase and a thiol oxidation-elicited subunit dimerization of protein kinase G in pulmonary artery relaxation to hydrogen peroxideHeme oxygenase-1 deficiency leads to alteration of soluble guanylate cyclase redox regulation.cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells.The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systemsSoluble guanylate cyclase: a new therapeutic target for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.Oxidation and loss of heme in soluble guanylyl cyclase from Manduca sexta.NOX1, 2, 4, 5: counting out oxidative stress.Roles for redox mechanisms controlling protein kinase G in pulmonary and coronary artery responses to hypoxiaDynamic ligand exchange in soluble guanylyl cyclase (sGC): implications for sGC regulation and desensitization.The COP9 signalosome and vascular function: intriguing possibilities?Cinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia/reperfusion injury: role of hydrogen sulfide.Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient miceCardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.Molecular model of a soluble guanylyl cyclase fragment determined by small-angle X-ray scattering and chemical cross-linking.Soluble guanylate cyclase redox state under oxidative stress conditions in isolated monkey coronary arteriesPreconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice.Translating the oxidative stress hypothesis into the clinic: NOX versus NOS.Modulation of soluble guanylate cyclase for the treatment of erectile dysfunction.The chemistry and biology of soluble guanylate cyclase stimulators and activators.The cGMP/PKG pathway as a common mediator of cardioprotection: translatability and mechanism.Regulation of sGC via hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives.Structure and Activation of Soluble Guanylyl Cyclase, the Nitric Oxide Sensor.Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway.Cinaciguat ameliorates glomerular damage by reducing ERK1/2 activity and TGF-ß expression in type-1 diabetic ratsRegulation of soluble guanylyl cyclase redox state by hydrogen sulfide.Dual pathways of carbon monoxide-mediated vasoregulation: modulation by redox mechanisms.Ido brings down the pressure in systemic inflammation.Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling.Redox Mechanisms Influencing cGMP Signaling in Pulmonary Vascular Physiology and Pathophysiology.
P2860
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P2860
Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteasomal degradation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Nitric oxide-independent vasod ...... from proteasomal degradation.
@en
Nitric oxide-independent vasod ...... from proteasomal degradation.
@nl
type
label
Nitric oxide-independent vasod ...... from proteasomal degradation.
@en
Nitric oxide-independent vasod ...... from proteasomal degradation.
@nl
prefLabel
Nitric oxide-independent vasod ...... from proteasomal degradation.
@en
Nitric oxide-independent vasod ...... from proteasomal degradation.
@nl
P2093
P1433
P1476
Nitric oxide-independent vasod ...... from proteasomal degradation.
@en
P2093
Harald H H W Schmidt
Kristina Gegenbauer
Kristina Wagner
Michael Karas
Nils Opitz
Peter M Schmidt
Sabine Meurer
Sandra Geschka
Simone Matt
Sylke Pioch
P356
10.1161/CIRCRESAHA.109.198234
P577
2009-05-28T00:00:00Z