Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line.
about
Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signalingThe novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cellsArsenic-mediated activation of the Nrf2-Keap1 antioxidant pathwayAlterations in glutathione levels and apoptotic regulators are associated with acquisition of arsenic trioxide resistance in multiple myelomaMetabolism, toxicity and anticancer activities of arsenic compounds.Dimethylarsinothioyl glutathione as a metabolite in human multiple myeloma cell lines upon exposure to DarinaparsinGlutathione S-conjugates as prodrugs to target drug-resistant tumors.The novel organic arsenical darinaparsin induces MAPK-mediated and SHP1-dependent cell death in T-cell lymphoma and Hodgkin lymphoma cells and human xenograft models.Hepatic and Nephric NRF2 Pathway Up-Regulation, an Early Antioxidant Response, in Acute Arsenic-Exposed Mice.Determination of multiple human arsenic metabolites employing high performance liquid chromatography inductively coupled plasma mass spectrometryDarinaparsin: a novel organic arsenical with promising anticancer activity.Anticancer activity of metal complexes: involvement of redox processes.Toxicogenomics-based identification of mechanisms for direct immunotoxicity.Extraction tool and matrix effects on arsenic speciation analysis in cell lines.Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer.Monitoring Response and Resistance to the Novel Arsenical Darinaparsin in an AML Patient.Multifactorial Modes of Action of Arsenic Trioxide in Cancer Cells as Analyzed by Classical and Network Pharmacology.
P2860
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P2860
Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Darinaparsin induces a unique ...... e-resistant myeloma cell line.
@en
Darinaparsin induces a unique ...... e-resistant myeloma cell line.
@nl
type
label
Darinaparsin induces a unique ...... e-resistant myeloma cell line.
@en
Darinaparsin induces a unique ...... e-resistant myeloma cell line.
@nl
prefLabel
Darinaparsin induces a unique ...... e-resistant myeloma cell line.
@en
Darinaparsin induces a unique ...... e-resistant myeloma cell line.
@nl
P2093
P2860
P1476
Darinaparsin induces a unique ...... e-resistant myeloma cell line.
@en
P2093
Alejo A Morales
Claire Croutch
Delia Gutman
Kelvin P Lee
Lawrence H Boise
Lucy Yehiayan
Shannon M Matulis
P2860
P304
P356
10.1158/1535-7163.MCT-08-1072
P577
2009-05-05T00:00:00Z