Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation.
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An overview of Cdk1-controlled targets and processesReplication licensing and cancer--a fatal entanglement?DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions.Xbp1 directs global repression of budding yeast transcription during the transition to quiescence and is important for the longevity and reversibility of the quiescent stateReplication stress in Mammalian cells and its consequences for mitosisCDC6: from DNA replication to cell cycle checkpoints and oncogenesisCellular checkpoint mechanisms monitoring proper initiation of DNA replicationMathematical modelling of DNA replication reveals a trade-off between coherence of origin activation and robustness against rereplicationActivation of the DNA damage checkpoint and genomic instability in human precancerous lesionsAcute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation.DNA replication stress is a determinant of chronological lifespan in budding yeast.H2A.Z functions to regulate progression through the cell cycle.Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination.mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongueIncreased genome instability and telomere length in the elg1-deficient Saccharomyces cerevisiae mutant are regulated by S-phase checkpoints.Multiple regulatory mechanisms to inhibit untimely initiation of DNA replication are important for stable genome maintenance.The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.Regulation of gross chromosomal rearrangements by ubiquitin and SUMO ligases in Saccharomyces cerevisiae.Suppression of gross chromosomal rearrangements by yKu70-yKu80 heterodimer through DNA damage checkpoints.The Rad1-Rad10 complex promotes the production of gross chromosomal rearrangements from spontaneous DNA damage in Saccharomyces cerevisiaeGenomic instability and cancer: lessons learned from human papillomaviruses.Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae.DNA replication origin interference increases the spacing between initiation events in human cells.Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATRMechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage.The cyclin-dependent kinase inhibitor Dacapo promotes replication licensing during Drosophila endocycles.Three Different Pathways Prevent Chromosome Segregation in the Presence of DNA Damage or Replication Stress in Budding YeastGenomic specification and epigenetic regulation of eukaryotic DNA replication originsFork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability.Msa1 and Msa2 Modulate G1-Specific Transcription to Promote G1 Arrest and the Transition to Quiescence in Budding Yeast.Deregulation of cyclin E in human cells interferes with prereplication complex assembly.Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication.Reducing MCM levels in human primary T cells during the G(0)-->G(1) transition causes genomic instability during the first cell cycleSmc5-Smc6 complex suppresses gross chromosomal rearrangements mediated by break-induced replications.p19(Arf) is required for the cellular response to chronic DNA damageThe Cyclin-dependent kinase inhibitor Dacapo promotes genomic stability during premeiotic S phase.Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy.Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae.
P2860
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P2860
Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Deregulated G1-cyclin expressi ...... ng efficient pre-RC formation.
@en
Deregulated G1-cyclin expressi ...... ng efficient pre-RC formation.
@nl
type
label
Deregulated G1-cyclin expressi ...... ng efficient pre-RC formation.
@en
Deregulated G1-cyclin expressi ...... ng efficient pre-RC formation.
@nl
prefLabel
Deregulated G1-cyclin expressi ...... ng efficient pre-RC formation.
@en
Deregulated G1-cyclin expressi ...... ng efficient pre-RC formation.
@nl
P2860
P356
P1433
P1476
Deregulated G1-cyclin expressi ...... ng efficient pre-RC formation.
@en
P2860
P304
P356
10.1101/GAD.1011002
P577
2002-10-01T00:00:00Z