Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.
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Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infectionPhosphorylation of the autophagy receptor optineurin restricts Salmonella growthVaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7The sst1 resistance locus regulates evasion of type I interferon signaling by Chlamydia pneumoniae as a disease tolerance mechanismTick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathwayIdentification of Novel Inhibitors of the Type I Interferon Induction Pathway Using Cell-Based High-Throughput ScreeningGenetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITORStructural Insights into the Functions of TBK1 in Innate Antimicrobial ImmunityTargeting TBK1 inhibits migration and resistance to MEK inhibitors in mutant NRAS melanoma.PI3K-independent AKT activation in cancers: a treasure trove for novel therapeuticsDevelopment of a high-throughput assay for identifying inhibitors of TBK1 and IKKεA Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of OptineurinTBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome MaturationTLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentationDifferential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins.Systems-level comparison of host-responses elicited by avian H5N1 and seasonal H1N1 influenza viruses in primary human macrophages.P16INK4a upregulation mediated by TBK1 induces retinal ganglion cell senescence in ischemic injury.Functional dissection of the TBK1 molecular networkIdentification of a novel in vivo virus-targeted phosphorylation site in interferon regulatory factor-3 (IRF3)Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon.Intracellular sensing of complement C3 activates cell autonomous immunity.Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages.Identification of small-molecule inhibitors of the ribonuclease H2 enzyme.Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1.Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions.TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformationA systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1β, [corrected] TNF-α and IL-6 challenges in C57BL/6 miceARF6 inhibition stabilizes the vasculature and enhances survival during endotoxic shock.TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I.Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1A KALA-modified lipid nanoparticle containing CpG-free plasmid DNA as a potential DNA vaccine carrier for antigen presentation and as an immune-stimulative adjuvant.Functionally distinct effects of the C-terminal regions of IKKε and TBK1 on type I IFN productionHydroxychloroquine-inhibited dengue virus is associated with host defense machinery.Loss of compensatory pro-survival and anti-apoptotic modulator, IKKε, sensitizes ovarian cancer cells to CHEK1 loss through an increased level of p21.Visualizing toll-like receptor-dependent phagosomal dynamics in murine dendritic cells using live cell microscopy.Analyses of the pathways involved in early- and late-phase induction of IFN-beta during C. muridarum infection of oviduct epithelial cellsThe TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.Inhibitors of the interferon response enhance virus replication in vitro.Tom70 mediates Sendai virus-induced apoptosis on mitochondria.Type I interferon response is delayed in human astrovirus infections.
P2860
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P2860
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Use of the pharmacological inh ...... hosphorylation and activation.
@en
Use of the pharmacological inh ...... hosphorylation and activation.
@nl
type
label
Use of the pharmacological inh ...... hosphorylation and activation.
@en
Use of the pharmacological inh ...... hosphorylation and activation.
@nl
prefLabel
Use of the pharmacological inh ...... hosphorylation and activation.
@en
Use of the pharmacological inh ...... hosphorylation and activation.
@nl
P2093
P2860
P356
P1476
Use of the pharmacological inh ...... hosphorylation and activation.
@en
P2093
Kristopher Clark
Lorna Plater
Mark Peggie
Philip Cohen
P2860
P304
14136-14146
P356
10.1074/JBC.M109.000414
P407
P577
2009-03-22T00:00:00Z