Oncogenic functions of PTK6 are enhanced by its targeting to plasma membrane but abolished by its targeting to nucleus.
about
The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1Protein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrateProtein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factorPTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.Detection of Brk expression in non-small cell lung cancer: clinicopathological relevance.The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-cateninThe associated pyrazolopyrimidines PP1 and PP2 inhibit protein tyrosine kinase 6 activity and suppress breast cancer cell proliferation.PTK6 regulates IGF-1-induced anchorage-independent survival.Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRKBreast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis.Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis.Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer.Understanding the cellular roles of Fyn-related kinase (FRK): implications in cancer biology.PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.Targeting protein tyrosine kinase 6 enhances apoptosis of colon cancer cells following DNA damage.PTK6 Localized at the Plasma Membrane Promotes Cell Proliferation and MigratiOn Through Phosphorylation of Eps8.Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
P2860
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P2860
Oncogenic functions of PTK6 are enhanced by its targeting to plasma membrane but abolished by its targeting to nucleus.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Oncogenic functions of PTK6 ar ...... d by its targeting to nucleus.
@en
Oncogenic functions of PTK6 ar ...... d by its targeting to nucleus.
@nl
type
label
Oncogenic functions of PTK6 ar ...... d by its targeting to nucleus.
@en
Oncogenic functions of PTK6 ar ...... d by its targeting to nucleus.
@nl
prefLabel
Oncogenic functions of PTK6 ar ...... d by its targeting to nucleus.
@en
Oncogenic functions of PTK6 ar ...... d by its targeting to nucleus.
@nl
P2860
P356
P1476
Oncogenic functions of PTK6 ar ...... d by its targeting to nucleus.
@en
P2093
Han Ie Kim
P2860
P304
P356
10.1093/JB/MVP050
P577
2009-03-20T00:00:00Z