Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5.
about
Structural insights from binding poses of CCR2 and CCR5 with clinically important antagonists: a combined in silico studyLigand- and mutation-induced conformational selection in the CCR5 chemokine G protein-coupled receptorLigand supported homology modeling and docking evaluation of CCR2: docked pose selection by consensus scoring.The use of G-protein coupled receptor models in lead optimization.CCR9-mediated signaling through β-catenin and identification of a novel CCR9 antagonist.Structural Analysis of Chemokine Receptor-Ligand Interactions.CXCR3 antagonist VUF10085 binds to an intrahelical site distinct from that of the broad spectrum antagonist TAK-779.Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice.Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.Targeting chemokine receptors in allergic disease.Pharmacological modulation of chemokine receptor function.A dual CCR2/CCR5 chemokine antagonist, BMS-813160? Evaluation of WO2011046916.CCR5 inhibitors: emergence, success, and challenges.Rational design of CCR2 antagonists: a survey of computational studies.Progress in the discovery of CC chemokine receptor 2 antagonists, 2009 - 2012.Successes and failures of chemokine-pathway targeting in rheumatoid arthritis.New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.Designing small molecule CXCR3 antagonists.Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV.Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2.Structure prediction and molecular dynamics simulations of a G-protein coupled receptor: human CCR2 receptor.Molecular dynamics simulation of chemokine receptors in lipid bilayer: a case study on C-C chemokine receptor type 2.
P2860
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P2860
Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Elucidation of binding sites o ...... okine receptors CCR2 and CCR5.
@en
Elucidation of binding sites o ...... okine receptors CCR2 and CCR5.
@nl
type
label
Elucidation of binding sites o ...... okine receptors CCR2 and CCR5.
@en
Elucidation of binding sites o ...... okine receptors CCR2 and CCR5.
@nl
prefLabel
Elucidation of binding sites o ...... okine receptors CCR2 and CCR5.
@en
Elucidation of binding sites o ...... okine receptors CCR2 and CCR5.
@nl
P2093
P50
P356
P1476
Elucidation of binding sites o ...... mokine receptors CCR2 and CCR5
@en
P2093
Deborah Chen
Emma L Wise
James E Pease
Julie Kanjanapangka
Paymann Harirchian
Richard Horuk
Sabine Schyler
Sofia Ribeiro
Spencer E Hall
P304
P356
10.1124/MOL.108.053470
P577
2009-03-18T00:00:00Z