Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions.
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Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteinsThe mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4.Effect of bovine papillomavirus E2 protein-specific monoclonal antibodies on papillomavirus DNA replication.Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation functionIdentification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activityBrd4-independent transcriptional repression function of the papillomavirus e2 proteinsThe viral etiology of AIDS-associated malignanciesFunctional interaction of a novel cellular protein with the papillomavirus E2 transactivation domainConserved interaction of the papillomavirus E2 transcriptional activator proteins with human and yeast TFIIB proteins.Conditional mutations in the mitotic chromosome binding function of the bovine papillomavirus type 1 E2 protein.Variant upstream regulatory region sequences differentially regulate human papillomavirus type 16 DNA replication throughout the viral life cycle.Transactivation by the E2 protein of oncogenic human papillomavirus type 31 is not essential for early and late viral functions.The Epstein-Barr virus lytic transactivator Zta interacts with the helicase-primase replication proteins.Mechanisms of human papillomavirus E2-mediated repression of viral oncogene expression and cervical cancer cell growth inhibition.Role of the ATP-binding domain of the human papillomavirus type 11 E1 helicase in E2-dependent binding to the originNCoR1 mediates papillomavirus E8;E2C transcriptional repressionHuman papillomavirus type 16 E1circumflexE4 contributes to multiple facets of the papillomavirus life cycle.Nuclear export of human papillomavirus type 31 E1 is regulated by Cdk2 phosphorylation and required for viral genome maintenance.A transactivator function of cottontail rabbit papillomavirus e2 is essential for tumor induction in rabbits.Human papillomavirus type 16 E2 protein has no effect on transcription from episomal viral DNA.Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA.Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways.Brd4 is displaced from HPV replication factories as they expand and amplify viral DNABrd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses.Replication and partitioning of papillomavirus genomes.Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replicationEvolutionary variation of papillomavirus E2 protein and E2 binding sites.Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replication.Functional interactions between papillomavirus E1 and E2 proteins.A conserved N-terminal domain mediates required DNA replication activities and phosphorylation of the transcriptional activator IE1 of Autographa californica multicapsid nucleopolyhedrovirusHPV16 and 18 genome amplification show different E4-dependence, with 16E4 enhancing E1 nuclear accumulation and replicative efficiency via its cell cycle arrest and kinase activation functions.Targeting human papillomavirus genome replication for antiviral drug discoveryAn interaction between human papillomavirus 16 E2 and TopBP1 is required for optimum viral DNA replication and episomal genome establishmentP53 represses human papillomavirus type 16 DNA replication via the viral E2 proteinFailure to interact with Brd4 alters the ability of HPV16 E2 to regulate host genome expression and cellular movementCurrent understanding of the role of the Brd4 protein in the papillomavirus lifecycle.Human papillomavirus type 16 E2 and E6 are RNA-binding proteins and inhibit in vitro splicing of pre-mRNAs with suboptimal splice sitesThe papillomavirus E2 proteinsBrd4 Activates Early Viral Transcription upon Human Papillomavirus 18 Infection of Primary Keratinocytes.
P2860
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P2860
Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Targeted mutagenesis of the hu ...... and DNA replication functions.
@en
Targeted mutagenesis of the hu ...... and DNA replication functions.
@nl
type
label
Targeted mutagenesis of the hu ...... and DNA replication functions.
@en
Targeted mutagenesis of the hu ...... and DNA replication functions.
@nl
prefLabel
Targeted mutagenesis of the hu ...... and DNA replication functions.
@en
Targeted mutagenesis of the hu ...... and DNA replication functions.
@nl
P2093
P2860
P1433
P1476
Targeted mutagenesis of the hu ...... and DNA replication functions.
@en
P2093
P2860
P304
P407
P577
1996-03-01T00:00:00Z