Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
about
The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complexGeneration of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrinA High-Efficiency Cellular Extraction System for Biological ProteomicsBeta-amyloid precursor protein mutants respond to gamma-secretase modulatorsPresenilin/γ-secretase regulates neurexin processing at synapsesAn overview of APP processing enzymes and products.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.Chronic treatment with a novel γ-secretase modulator, JNJ-40418677, inhibits amyloid plaque formation in a mouse model of Alzheimer's disease.Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.Solution NMR approaches for establishing specificity of weak heterodimerization of membrane proteinsPresenilins and γ-secretase: structure, function, and role in Alzheimer Disease.Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's DiseaseThe protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging.Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.The structure and function of Alzheimer's gamma secretase enzyme complex.Pharmacological targeting of the β-amyloid precursor protein intracellular domain.Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics.Novel γ-secretase enzyme modulators directly target presenilin protein.Reproducible method to enrich membrane proteins with high purity and high yield for an LC-MS/MS approach in quantitative membrane proteomics.In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness.Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process.Human brain proteins showing neuron-specific interactions with γ-secretase.Regulated intramembrane proteolysis: emergent role in cell signalling pathways.Binding of Bexarotene to the Amyloid Precursor Protein Transmembrane Domain in Liposomes Alters its α-Helical Conformation but Inhibits γ-Secretase Non-Selectively.
P2860
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P2860
Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Purification, pharmacological ...... ogenous human gamma-secretase.
@en
Purification, pharmacological ...... ogenous human gamma-secretase.
@nl
type
label
Purification, pharmacological ...... ogenous human gamma-secretase.
@en
Purification, pharmacological ...... ogenous human gamma-secretase.
@nl
prefLabel
Purification, pharmacological ...... ogenous human gamma-secretase.
@en
Purification, pharmacological ...... ogenous human gamma-secretase.
@nl
P2093
P356
P1433
P1476
Purification, pharmacological ...... ogenous human gamma-secretase.
@en
P2093
Akio Fukumori
Birgit Dümpelfeld
Edith Winkler
Harald Steiner
Karlheinz Baumann
Scott Hobson
Thomas Luebbers
P304
P356
10.1021/BI801204G
P407
P577
2009-02-01T00:00:00Z