Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins.
about
Steroid Receptor-Associated Immunophilins: A Gateway to Steroid SignallingFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityConsecutive isocyanide-based multicomponent reactions: synthesis of cyclic pentadepsipeptoids.Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonistHitting a Moving Target: How Does an N-Methyl Group Impact Biological Activity?The Chemical Biology of Molecular Chaperones--Implications for Modulation of ProteostasisX66, a novel N-terminal heat shock protein 90 inhibitor, exerts antitumor effects without induction of heat shock responseHsp70 protein complexes as drug targets.A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response.Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects.C-terminal heat shock protein 90 modulators produce desirable oncogenic properties.Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold.Chiral resolution and pharmacological characterization of the enantiomers of the Hsp90 inhibitor 2-amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime.Alternative approaches to Hsp90 modulation for the treatment of cancer.The first report of direct inhibitors that target the C-terminal MEEVD region on heat shock protein 90.An Hsp90 modulator that exhibits a unique mechanistic profile.Chemically accessible hsp90 inhibitor that does not induce a heat shock responseA heat shock protein 90 inhibitor that modulates the immunophilins and regulates hormone receptors without inducing the heat shock responseSpecific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.Effectively delivering a unique hsp90 inhibitor using star polymers.Triazole Containing Novobiocin and Biphenyl Amides as Hsp90 C-Terminal Inhibitors.Dimerization of a heat shock protein 90 inhibitor enhances inhibitory activity.Expression of miR-711 and mechanism of proliferation and apoptosis in human gastric carcinoma.Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery.Reinventing Hsp90 Inhibitors: Blocking C-Terminal Binding Events to Hsp90 by Using Dimerized Inhibitors.Regulating the cytoprotective response in cancer cells using simultaneous inhibition of Hsp90 and Hsp70.
P2860
Q26801686-BBB39F8C-B48E-48FE-A760-F5D81D4F6257Q26996645-0F2EB54D-3A11-4C28-8F55-B8C928D51497Q30317250-AB12ED9F-DEC2-485E-B551-9243C90DE70BQ34832185-9275C816-6F4F-4245-9167-8F283BA1E0BAQ35902732-717DED79-3C16-4A26-8CFB-23E5F9C5BB98Q36059002-DA74CC37-CC3A-44F9-84DF-D001386D0732Q37301905-4462C8D4-C124-4AD9-9660-9F91F2FB39D1Q38037745-8CC0501B-EC15-4D79-904C-F08C497E1A6CQ38740513-B21B477A-F210-448A-B333-92D853B80470Q38750417-8A54A865-4EA3-491E-9A1E-FF899AD5FC9CQ38906493-3EC72D89-CCB8-4370-9B0F-9498FD6D11C9Q38912429-6C97B62F-B2A5-41AD-AD51-915B15095FF7Q39002157-49E2F382-F981-4250-ACAA-2DF1F521D2CEQ39103704-7B67D097-3467-4D04-8982-E56464CE8ED1Q40362044-D2639C30-163C-47B8-A05D-E89FA7EDD4E4Q41771962-F17AFA77-85A8-4F4F-AD08-77C23A6B1072Q41863286-B41512AD-2004-493D-9760-FB1B225BD218Q41864092-CCF9AFEB-BA67-4577-9002-4E0B0ABB21CBQ41884789-A2F1684B-129A-49AE-831F-84EAA6008922Q42774352-5106938F-41CB-4397-96AE-359C1FA80699Q42945545-D4FA7F98-5293-40B4-A717-ED5A3149739FQ45731359-4481AE18-4EC7-4777-B98A-331D72B0FB7EQ47162233-0F5E8407-FB85-4391-BEDF-D6E310E38076Q51000365-16FB3AB4-BAFF-4A02-85E9-368E7F28FF79Q51320269-77FCED06-4B5F-4642-9755-CA91C7B4FBD3Q53663668-A732BC41-E6C2-4F45-886A-60BCE894E3DA
P2860
Macrocycles that inhibit the binding between heat shock protein 90 and TPR-containing proteins.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Macrocycles that inhibit the b ...... 0 and TPR-containing proteins.
@en
Macrocycles that inhibit the b ...... 0 and TPR-containing proteins.
@nl
type
label
Macrocycles that inhibit the b ...... 0 and TPR-containing proteins.
@en
Macrocycles that inhibit the b ...... 0 and TPR-containing proteins.
@nl
prefLabel
Macrocycles that inhibit the b ...... 0 and TPR-containing proteins.
@en
Macrocycles that inhibit the b ...... 0 and TPR-containing proteins.
@nl
P2093
P2860
P356
P1433
P1476
Macrocycles that inhibit the b ...... 0 and TPR-containing proteins.
@en
P2093
Leslie D Alexander
Shelli R McAlpine
Veronica C Ardi
Victoria A Johnson
P2860
P304
P356
10.1021/CB200203M
P577
2011-10-17T00:00:00Z