Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.
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Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune DysfunctionHypoxia Inducible Factor Pathway and Physiological Adaptation: A Cell Survival Pathway?The potential of liposomes with carbonic anhydrase IX to deliver anticancer ingredients to cancer cells in vivoWays to enhance lymphocyte trafficking into tumors and fitness of tumor infiltrating lymphocytesRecent developments in targeting carbonic anhydrase IX for cancer therapeuticsCrystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IXDithiocarbamates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Action in VivoThe Structure of Carbonic Anhydrase IX Is Adapted for Low-pH CatalysisAutosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of Carbonic Anhydrase 12The spatial organization of proton and lactate transport in a rat brain tumorAcidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitorsTargeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitorsDefining the role of hypoxia-inducible factor 1 in cancer biology and therapeuticsThe tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis.Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice.Development and characterization of new monoclonal antibodies against human recombinant CA XII.Effects of nickel treatment on H3K4 trimethylation and gene expression.3'UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma.Near-infrared fluorescence activation probes based on disassembly-induced emission cyanine dye.High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancerRegulation of mTORC1 signaling by pHOverexpression of carbonic anhydrase and HIF-1α in Wilms tumours.Anticancer targets in the glycolytic metabolism of tumors: a comprehensive reviewNoninvasive detection of breast cancer lymph node metastasis using carbonic anhydrases IX and XII targeted imaging probes.Tumor microenvironmental changes induced by the sulfamate carbonic anhydrase IX inhibitor S4 in a laryngeal tumor modelThe human proton-coupled folate transporter: Biology and therapeutic applications to cancer.Acidity generated by the tumor microenvironment drives local invasionpH-Sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells.HIF-1α regulated tongue squamous cell carcinoma cell growth via regulating VEGF expression in a xenograft modelStructural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates.Role of hypoxia and EGF on expression, activity, localization and phosphorylation of carbonic anhydrase IX in MDA-MB-231 breast cancer cells.Computational design of a CNT carrier for a high affinity bispecific anti-HER2 antibody based on trastuzumab and pertuzumab Fabs.Silencing of hypoxia-inducible tumor suppressor lysyl oxidase gene by promoter methylation activates carbonic anhydrase IX in nasopharyngeal carcinoma.Human voltage-gated proton channel hv1: a new potential biomarker for diagnosis and prognosis of colorectal cancer.Catalysis and pH control by membrane-associated carbonic anhydrase IX in MDA-MB-231 breast cancer cellsNovel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells.Design, synthesis, and antitumor screening of certain novel tetrahydroquinoline sulfonamides.Identification of metal dithiocarbamates as a novel class of antileishmanial agentsCircadian cycles are the dominant transcriptional rhythm in the intertidal mussel Mytilus californianusCD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.
P2860
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P2860
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Hypoxia-inducible carbonic anh ...... ation of the intracellular pH.
@en
Hypoxia-inducible carbonic anh ...... ation of the intracellular pH.
@nl
type
label
Hypoxia-inducible carbonic anh ...... ation of the intracellular pH.
@en
Hypoxia-inducible carbonic anh ...... ation of the intracellular pH.
@nl
prefLabel
Hypoxia-inducible carbonic anh ...... ation of the intracellular pH.
@en
Hypoxia-inducible carbonic anh ...... ation of the intracellular pH.
@nl
P2093
P1433
P1476
Hypoxia-inducible carbonic anh ...... ation of the intracellular pH.
@en
P2093
Eric Trottier
Frédéric Dayan
Johanna Chiche
Julie Laferrière
Karine Ilc
M Christiane Brahimi-Horn
Nathalie M Mazure
P304
P356
10.1158/0008-5472.CAN-08-2470
P407
P577
2009-01-01T00:00:00Z