Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels.
about
A gain-of-function mutation in TRPA1 causes familial episodic pain syndromeStructure of the TRPA1 ion channel suggests regulatory mechanismsHow the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopyDeciphering Subtype-Selective Modulations in TRPA1 Biosensor ChannelsPokes, sunburn, and hot sauce: Drosophila as an emerging model for the biology of nociceptionTRPA1 as a drug target--promise and challengesModulation of thermoreceptor TRPM8 by cooling compoundsA Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating DomainSensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures.The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazoleDifferential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in MiceThe transient receptor potential channel TRPM8 is inhibited via the alpha 2A adrenoreceptor signaling pathwayActivation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with AsthmaActivation of transient receptor potential ankyrin-1 (TRPA1) in lung cells by wood smoke particulate materialStructural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences.Isoform-specific modulation of the chemical sensitivity of conserved TRPA1 channel in the major honeybee ectoparasitic mite, Tropilaelaps mercedesaeWhen Choice Makes Sense: Menthol Influence on Mating, Oviposition and Fecundity in Drosophila melanogasterOlfactory and trigeminal interaction of menthol and nicotine in humans.The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain.A clinical and mechanistic study of topical borneol-induced analgesiaAnalysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception.Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation.Cooling-sensitive TRPM8 is thermostat of skin temperature against cooling.Menthol response and adaptation in nociceptive-like and nonnociceptive-like neurons: role of protein kinases.CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch.TRPA1 is a polyunsaturated fatty acid sensor in mammalsAre sensory TRP channels biological alarms for lipid peroxidation?TRPA1: a transducer and amplifier of pain and inflammation.The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppressionSelf- and cross-desensitization of oral irritation by menthol and cinnamaldehyde (CA) via peripheral interactions at trigeminal sensory neurons.Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist.Enhancing effect of menthol on nicotine self-administration in ratsCold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROSHuman TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domainTemperature-dependent STIM1 activation induces Ca²+ influx and modulates gene expressionIdentification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil.Scraping through the ice: uncovering the role of TRPM8 in cold transductionNovel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity.Menthol Enhances the Desensitization of Human α3β4 Nicotinic Acetylcholine Receptors.Perceptual mapping of chemesthetic stimuli in naïve assessors.
P2860
Q24320280-2D453E3F-B960-4F5E-82BE-8956E8AE69FCQ24336461-78D08C02-A7C8-46EF-B017-79CAB712C2F6Q26783066-A88E6CA2-AB8C-4C33-B267-00E61598A655Q26786467-0C90CEE3-ED5D-438A-B091-0F2E1B0C75DCQ26862727-09FC2697-BBF2-4D7D-83D3-320648F81189Q26863458-83738245-4C53-4CD9-9566-A317834149A1Q27021645-FBC0B7E7-C38A-4399-ABC8-9778BC3003B7Q27681733-051BBAF2-51B4-4796-BB2D-A908C87411CBQ27693846-E05D704E-47F3-434A-A478-E079EAEBBED1Q28542707-07951660-5A50-41FD-B0E7-0E5A96692522Q28546749-8CDE443B-AC7D-4BF3-98D7-B7014D5CFA25Q28578194-7C675810-924C-40CE-B9E3-1622710D104DQ28601283-D8593643-D57E-4118-8CDB-62B07F483E0CQ28682208-83335267-3A6D-4DB8-8D5B-970566066D5CQ28820933-7B02A609-8F62-414F-BDD5-C857B1355A6CQ28831484-44892133-AF3F-4A29-80BD-153245E85F28Q30389217-46EEB6AD-1CC9-40B7-87EE-3FB9A13F7D0BQ30467556-4107BF9B-53E8-4B17-920F-8554553D8A1FQ33509286-BD6AA114-8CC4-4021-93E9-C6B61AFD1D1FQ33748959-A6402A0D-27F6-4566-9E49-E5EC884A6FE1Q33753976-CD302256-2919-4D6A-BDC4-85B156387D0EQ33775096-1916C0FF-DF54-4C96-BE11-00892BE3EED6Q33846996-4BD27DAA-9709-4A23-9F51-38E572EED432Q34114413-45681D7E-B63F-4820-8D34-1A25415B8AFFQ34260129-4DFBB1B3-F038-4B87-8F06-DE9CB5965DF7Q34313857-B8E27BD5-0DFF-4D13-B658-EC73146EF1EBQ34358689-0785530C-1FEA-43A8-BB5B-3FEA52882C49Q34376133-FB8BE75C-5B66-4588-9650-9AAA0D65903EQ34388766-98C53D7A-8BD0-4D00-A7CB-02DBBA2B1DB8Q34487275-3207982C-3BD2-4C42-BDDF-612D24583630Q34509697-2988E110-1BDB-4F82-955A-7A115613275CQ34535780-1F71A4E3-16DF-478C-BB3E-D54B2D506BD9Q34540308-C1187D7D-2658-4268-8120-61A3C3F36F26Q34601695-D58E33BA-9A98-41CF-A3D2-A8A6C20DBAA9Q34990337-1774ADAF-AD65-4160-AA6D-2A6C0CD699D1Q35048855-B203CDF0-BB96-469E-9269-21B4CFC8AC16Q35057198-6BE5CF33-5CD6-400F-BE57-7DD5F75ABFE7Q35162238-6A38ECB0-EB15-48D0-9618-EBFD1193D2FEQ35897852-577521A4-F782-4095-9DA3-A743C39ADE1EQ35899869-975957B3-9C43-40CD-A913-EA28D0DAB5ED
P2860
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Identification of transmembran ...... y in mammalian TRPA1 channels.
@en
Identification of transmembran ...... y in mammalian TRPA1 channels.
@nl
type
label
Identification of transmembran ...... y in mammalian TRPA1 channels.
@en
Identification of transmembran ...... y in mammalian TRPA1 channels.
@nl
prefLabel
Identification of transmembran ...... y in mammalian TRPA1 channels.
@en
Identification of transmembran ...... y in mammalian TRPA1 channels.
@nl
P2093
P2860
P1476
Identification of transmembran ...... y in mammalian TRPA1 channels.
@en
P2093
Adrienne E Dubin
Ardem Patapoutian
Badry Bursulaya
Bailong Xiao
Timothy J Jegla
Veena Viswanath
P2860
P304
P356
10.1523/JNEUROSCI.2772-08.2008
P407
P577
2008-09-01T00:00:00Z