Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists
about
Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activationHuman embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegenerationSpecies-specific temperature sensitivity of TRPA1Deciphering Subtype-Selective Modulations in TRPA1 Biosensor ChannelsTRPA1 as a drug target--promise and challengesStructural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences.Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function.High throughput screening for inhibitors of alpha-galactosidase.The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppressionAMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodyniaActivation characteristics of transient receptor potential ankyrin 1 and its role in nociception.1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1.TRPA1 and cold transduction: an unresolved issue?Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats.Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity.TRPA1 modulators in preclinical development.Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents.Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.Recent advances in the biology and medicinal chemistry of TRPA1.Current perspectives on the modulation of thermo-TRP channels: new advances and therapeutic implications.TRP channels as therapeutic targets in airway disorders: a patent review.Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegenerationTransforming TRP channel drug discovery using medium-throughput electrophysiological assays.Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells.Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels.Transient receptor potential melastatin 8 (TRPM8) channels are involved in body temperature regulationThe roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity.TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1.Characterization of a ligand binding site in the human transient receptor potential ankyrin 1 pore.TRPA1: the species differenceZinc inactivates melastatin transient receptor potential 2 channels via the outer pore.In vitro pharmacological characterization of a novel TRPA1 antagonist and proof of mechanism in a human dental pulp model.Identification of molecular determinants for a potent mammalian TRPA1 antagonist by utilizing species differences.2-Amino-4-arylthiazole compounds as TRPA1 antagonists (WO 2012085662): a patent evaluation.Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature.A residue in the TRPM2 channel outer pore is crucial in determining species-dependent sensitivity to extracellular acidic pH
P2860
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P2860
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists
description
2007 nî lūn-bûn
@nan
2007 թուականին հրատարակուած գիտական յօդուած
@hyw
2007 թվականին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@ast
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@en
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@en-gb
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@nl
type
label
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@ast
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@en
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@en-gb
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@nl
prefLabel
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@ast
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@en
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@en-gb
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@nl
P2093
P2860
P921
P356
P1433
P1476
Species-specific pharmacology ...... ankyrin 1 (TRPA1) antagonists
@en
P2093
David C Immke
Lana Klionsky
Narender R Gavva
Nobuko Nishimura
Rami Tamir
Weiya Wang
P2860
P2888
P356
10.1186/1744-8069-3-39
P407
P577
2007-01-01T00:00:00Z
P5875
P6179
1009787504