Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression. - Wikidata - awgldk - TriplyDB

Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression.

Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression.

http://www.wikidata.org/entity/Q39941224

about

Allosteric antibody inhibition of human hepsin protease Laminin-332-beta1 integrin interactions negatively regulate invadopodia Prostate cancer progression and metastasis: potential regulatory pathways for therapeutic targeting.Evaluation of pulsed high intensity focused ultrasound exposures on metastasis in a murine model.ZEB1 coordinately regulates laminin-332 and {beta}4 integrin expression altering the invasive phenotype of prostate cancer cells Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells.Accurate molecular classification of cancer using simple rules Association of hepsin gene variants with prostate cancer risk and prognosis Defining the role of laminin-332 in carcinoma.Hepsin cooperates with MYC in the progression of adenocarcinoma in a prostate cancer mouse model.An allosteric anti-hepsin antibody derived from a constrained phage display library.Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries Aging-related alterations in the extracellular matrix modulate the microenvironment and influence tumor progression.The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis.Matrix-dependent regulation of AKT in Hepsin-overexpressing PC3 prostate cancer cells.Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior.Integrative analyses identify osteopontin, LAMB3 and ITGB1 as critical pro-metastatic genes for lung cancer.The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.Hepatitis B virus X protein binding to hepsin promotes C3 production by inducing IL-6 secretion from hepatocytes.Membrane-anchored serine proteases in health and disease.Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4 Components of cell-matrix linkage as potential new markers for prostate cancer.Integrin alpha6 maintains the structural integrity of the kidney collecting system.HLA-A2-restricted cytotoxic T lymphocyte epitopes from human hepsin as novel targets for prostate cancer immunotherapy.Membrane-bound and exosomal metastasis-associated C4.4A promotes migration by associating with the α(6)β(4) integrin and MT1-MMP.A reporter mouse model for in vivo tracing and in vitro molecular studies of melanocytic lineage cells and their diseases.Skin basement membrane: the foundation of epidermal integrity--BM functions and diverse roles of bridging molecules nidogen and perlecan.Molecular and physiological mechanisms of membrane receptor systems functioning.The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover.Analyzing the Type II Transmembrane Serine Protease Hepsin-Dependent Basement Membrane Remodeling in 3D Cell Culture.Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice.Mouse models of prostate cancer

P2860

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P2860

Laminin-332 is a substrate for hepsin, a protease associated with prostate cancer progression.

http://www.wikidata.org/entity/Q39941224

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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name

Laminin-332 is a substrate for ...... h prostate cancer progression.

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Laminin-332 is a substrate for ...... h prostate cancer progression.

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type

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Laminin-332 is a substrate for ...... h prostate cancer progression.

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Laminin-332 is a substrate for ...... h prostate cancer progression.

@nl

prefLabel

Laminin-332 is a substrate for ...... h prostate cancer progression.

@en

Laminin-332 is a substrate for ...... h prostate cancer progression.

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P1433

Journal of Biological Chemistry

P1476

Laminin-332 is a substrate for ...... h prostate cancer progression.

@en

P2093

Daniel Kirchhofer

http://www.w3.org/2001/XMLSchema#string

Hironobu Yamashita

http://www.w3.org/2001/XMLSchema#string

Manisha Tripathi

http://www.w3.org/2001/XMLSchema#string

Rajkumar Ganesan

http://www.w3.org/2001/XMLSchema#string

Srinivas Nandana

http://www.w3.org/2001/XMLSchema#string

Vito Quaranta

http://www.w3.org/2001/XMLSchema#string

P2860

Pro-urokinase-type plasminogen activator is a substrate for hepsin

The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain

Cancer statistics, 2008

Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2.

Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain

KLF6, a candidate tumor suppressor gene mutated in prostate cancer

Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B

Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5

A simplified laminin nomenclature

NC1 domain of type VII collagen binds to the beta3 chain of laminin 5 via a unique subdomain within the fibronectin-like repeats

P304

30576-30584

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scholarly article

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10.1074/JBC.M802312200

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45

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283

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2008-09-09T00:00:00Z

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18784072

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P932

2576550

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