ATR couples FANCD2 monoubiquitination to the DNA-damage response. - Wikidata - awgldk - TriplyDB

ATR couples FANCD2 monoubiquitination to the DNA-damage response.

ATR couples FANCD2 monoubiquitination to the DNA-damage response.

http://www.wikidata.org/entity/Q39941293

about

UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination.CtIP is required to initiate replication-dependent interstrand crosslink repair The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair Cdc5L interacts with ATR and is required for the S-phase cell-cycle checkpoint Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest Susceptibility pathways in Fanconi's anemia and breast cancer How the fanconi anemia pathway guards the genome A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway When heat casts a spell on the DNA damage checkpoints Fanconi anemia and the cell cycle: new perspectives on aneuploidy Regulation of monoubiquitinated PCNA by DUB autocleavage Chemical strategies for development of ATR inhibitors FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights Overexpression of Rad51C splice variants in colorectal tumors MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability Advances in understanding the complex mechanisms of DNA interstrand cross-link repair Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability Expanded roles of the Fanconi anemia pathway in preserving genomic stability The Fanconi anemia pathway and ubiquitin ATR: an essential regulator of genome integrity ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions.ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication.Fanconi anemia complementation group FANCD2 protein serine 331 phosphorylation is important for fanconi anemia pathway function and BRCA2 interaction.ATM-mediated transcriptional and developmental responses to gamma-rays in Arabidopsis The role of the Fanconi anemia network in the response to DNA replication stress.Fanconi anemia proteins and their interacting partners: a molecular puzzle Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication Regulation of PCNA polyubiquitination in human cells.

P2860

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P2860

ATR couples FANCD2 monoubiquitination to the DNA-damage response.

http://www.wikidata.org/entity/Q39941293

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

@zh-cn

name

ATR couples FANCD2 monoubiquitination to the DNA-damage response.

@en

ATR couples FANCD2 monoubiquitination to the DNA-damage response.

@nl

type

label

ATR couples FANCD2 monoubiquitination to the DNA-damage response.

@en

ATR couples FANCD2 monoubiquitination to the DNA-damage response.

@nl

prefLabel

ATR couples FANCD2 monoubiquitination to the DNA-damage response.

@en

ATR couples FANCD2 monoubiquitination to the DNA-damage response.

@nl

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ATR couples FANCD2 monoubiquitination to the DNA-damage response.

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Alan D D'Andrea

http://www.w3.org/2001/XMLSchema#string

Paul R Andreassen

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Toshiyasu Taniguchi

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P2860

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha

NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

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16

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18

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