Etomidate, propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant alpha4beta3delta and alpha4beta3 GABA A receptors expressed in HEK cells.
about
Fragrant dioxane derivatives identify beta1-subunit-containing GABAA receptorsRobust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue.Altered localization of the δ subunit of the GABAA receptor in the thalamus of α4 subunit knockout miceStoichiometry of expressed alpha(4)beta(2)delta gamma-aminobutyric acid type A receptors depends on the ratio of subunit cDNA transfected.Barbiturates require the N terminus and first transmembrane domain of the delta subunit for enhancement of alpha1beta3delta GABAA receptor currentsAlcohol- and alcohol antagonist-sensitive human GABAA receptors: tracking δ subunit incorporation into functional receptors.GABAA receptor modulation by neurosteroids in models of temporal lobe epilepsies.Changes in ventral respiratory column GABAaR ε- and δ-subunits during hibernation mediate resistance to depression by EtOH and pentobarbital.A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptorsBehavioral pharmacogenetic analysis on the role of the α4 GABA(A) receptor subunit in the ethanol-mediated impairment of hippocampus-dependent contextual learning.In vitro gamma oscillations following partial and complete ablation of δ subunit-containing GABAA receptors from parvalbumin interneurons.An allosteric coagonist model for propofol effects on α1β2γ2L γ-aminobutyric acid type A receptors.Etomidate uniquely modulates the desensitization of recombinant α1β3δ GABA(A) receptors.GABAA receptors increase excitability and conduction velocity of cerebellar parallel fiber axonsCharacteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.Assessment of subunit-dependent direct gating and allosteric modulatory effects of carisoprodol at GABA(A) receptors.The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptorsAltered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneuronsDihydropyrimidinone positive modulation of delta-subunit-containing gamma-aminobutyric acid type A receptors, including an epilepsy-linked mutant variant.Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability.Function and modulation of delta-containing GABA(A) receptorsGABAA-R α4 subunits are required for the low dose locomotor stimulatory effect of alphaxalone, but not for several other behavioral responses to alphaxalone, etomidate or propofolEtomidate produces similar allosteric modulation in α1β3δ and α1β3γ2L GABA(A) receptors.Modulation of Tonic GABA Currents by Anion Channel and Connexin Hemichannel Antagonists.Methylene blue inhibits GABAA receptors by interaction with GABA binding site.The general anesthetic propofol induces ictal-like seizure activity in hippocampal mouse brain slices.Propofol produces immobility via action in the ventral horn of the spinal cord by a GABAergic mechanism.Comparison of αβδ and αβγ GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics.Allosteric Modulation of αβδ GABAA Receptors.
P2860
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P2860
Etomidate, propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant alpha4beta3delta and alpha4beta3 GABA A receptors expressed in HEK cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Etomidate, propofol and the ne ...... eptors expressed in HEK cells.
@en
Etomidate, propofol and the ne ...... eptors expressed in HEK cells.
@nl
type
label
Etomidate, propofol and the ne ...... eptors expressed in HEK cells.
@en
Etomidate, propofol and the ne ...... eptors expressed in HEK cells.
@nl
prefLabel
Etomidate, propofol and the ne ...... eptors expressed in HEK cells.
@en
Etomidate, propofol and the ne ...... eptors expressed in HEK cells.
@nl
P2093
P2860
P1433
P1476
Etomidate, propofol and the ne ...... eptors expressed in HEK cells.
@en
P2093
Martin Wallner
Pratap Meera
Richard W Olsen
Thomas S Otis
P2860
P304
P356
10.1016/J.NEUROPHARM.2008.08.011
P577
2008-08-20T00:00:00Z