Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.
about
Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanismspARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular traffickingAxonal transport: cargo-specific mechanisms of motility and regulationAllele-specific silencing of mutant huntingtin in rodent brain and human stem cellsHuntingtin's function in axonal transport is conserved in Drosophila melanogasterScalable production in human cells and biochemical characterization of full-length normal and mutant huntingtinPrecursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processingThe regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.Axonal transport and neurodegenerative disease: can we see the elephant?Serine 421 regulates mutant huntingtin toxicity and clearance in mice.Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease.Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease miceThe Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling.Huntingtin acts non cell-autonomously on hippocampal neurogenesis and controls anxiety-related behaviors in adult mouseA small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice.Specific roles of Akt iso forms in apoptosis and axon growth regulation in neurons.Targets for future clinical trials in Huntington's disease: what's in the pipeline?Does Huntingtin play a role in selective macroautophagy?Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane.A huntingtin peptide inhibits polyQ-huntingtin associated defectsBDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity.Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.DISC1 regulates synaptic vesicle transport via a lithium-sensitive pathway.Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.Dysregulation of BDNF-TrkB signaling in developing hippocampal neurons by Pb(2+): implications for an environmental basis of neurodevelopmental disordersHuntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase.Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1.Mass spectrometric identification of novel posttranslational modification sites in Huntingtin.Huntingtin as an essential integrator of intracellular vesicular trafficking.Protein aggregates in Huntington's disease.Repeat expansion disease: progress and puzzles in disease pathogenesisSmall changes, big impact: posttranslational modifications and function of huntingtin in Huntington disease.Androgen function in the pathophysiology and treatment of male Huntington's disease patients.Targeting Huntington's disease through histone deacetylases.Integrated regulation of motor-driven organelle transport by scaffolding proteins.Huntington's Disease: Pathogenic Mechanisms and Therapeutic Targets.Exosomes and Homeostatic Synaptic Plasticity Are Linked to Each other and to Huntington's, Parkinson's, and Other Neurodegenerative Diseases by Database-Enabled Analyses of Comprehensively Curated Datasets.Huntington's disease: Molecular basis of pathology and status of current therapeutic approachesUnraveling the Role of Huntingtin in Breast Cancer Metastasis.
P2860
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P2860
Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Phosphorylation of mutant hunt ...... trograde transport in neurons.
@en
Phosphorylation of mutant hunt ...... trograde transport in neurons.
@nl
type
label
Phosphorylation of mutant hunt ...... trograde transport in neurons.
@en
Phosphorylation of mutant hunt ...... trograde transport in neurons.
@nl
prefLabel
Phosphorylation of mutant hunt ...... trograde transport in neurons.
@en
Phosphorylation of mutant hunt ...... trograde transport in neurons.
@nl
P2860
P50
P356
P1476
Phosphorylation of mutant hunt ...... etrograde transport in neurons
@en
P2093
Emilie Colin
Hélène Rangone
P2860
P304
P356
10.1093/HMG/DDN281
P577
2008-09-04T00:00:00Z