Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.
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Proteases in agricultural dust induce lung inflammation through PAR-1 and PAR-2 activationAirway epithelial epidermal growth factor receptor mediates hogbarn dust-induced cytokine release but not Ca2+ responseMeprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3Neutrophil-Derived Proteases in the Microenvironment of Pancreatic Cancer -Active Players in Tumor ProgressionStructural basis for the sheddase function of human meprin metalloproteinase at the plasma membraneInhibition of human neutrophil elastase by pentacyclic triterpenesTransactivation of the epidermal growth factor receptor by heat shock protein 90 via Toll-like receptor 4 contributes to the migration of glioblastoma cells.Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2.ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A.Breaking barriers. New insights into airway epithelial barrier function in health and disease.From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease.Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.Urinary signatures of Renal Cell Carcinoma investigated by peptidomic approaches.Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease.Pulmonary proteases in the cystic fibrosis lung induce interleukin 8 expression from bronchial epithelial cells via a heme/meprin/epidermal growth factor receptor/Toll-like receptor pathway.Activation of the epithelial sodium channel by the metalloprotease meprin β subunit.Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo.Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substratesTranscription of Interleukin-8: How Altered Regulation Can Affect Cystic Fibrosis Lung Disease.Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migrationThe substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung.Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery.Human copper transporter 1 lacking O-linked glycosylation is proteolytically cleaved in a Rab9-positive endosomal compartment.Tetraspanins Function as Regulators of Cellular Signaling.The cystic fibrosis neutrophil: a specialized yet potentially defective cell.The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and α-1 anti-trypsin deficiency.EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice.S100A8, S100A9 and S100A12 activate airway epithelial cells to produce MUC5AC via extracellular signal-regulated kinase and nuclear factor-κB pathways.Targeting miRNA-based medicines to cystic fibrosis airway epithelial cells using nanotechnologyRole of LPS-elicited signaling in triggering gastric mucosal inflammatory responses to H. pylori: modulatory effect of ghrelin.Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.MicroRNA Expression in Cystic Fibrosis Airway Epithelium.Helicobacter pylori-induced gastric mucosal TGF-α ectodomain shedding and EGFR transactivation involves Rac1/p38 MAPK-dependent TACE activation.MEP1A contributes to tumor progression and predicts poor clinical outcome in human hepatocellular carcinoma.Cinnoline derivatives as human neutrophil elastase inhibitors.Neutrophil elastase modulates cytokine expression: contribution to host defense against Pseudomonas aeruginosa-induced pneumonia.Leishmania inhibitor of serine peptidase 2 prevents TLR4 activation by neutrophil elastase promoting parasite survival in murine macrophages.17Beta-estradiol inhibits IL-8 in cystic fibrosis by up-regulating secretory leucoprotease inhibitor.
P2860
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P2860
Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Activation of the epidermal gr ...... novel metalloprotease pathway.
@en
Activation of the epidermal growth factor receptor
@nl
type
label
Activation of the epidermal gr ...... novel metalloprotease pathway.
@en
Activation of the epidermal growth factor receptor
@nl
prefLabel
Activation of the epidermal gr ...... novel metalloprotease pathway.
@en
Activation of the epidermal growth factor receptor
@nl
P2093
P2860
P356
P1476
Activation of the epidermal gr ...... novel metalloprotease pathway
@en
P2093
Abderrazzaq Belaaouaj
Cliona Kenna
David A Bergin
Erwin E Sterchi
Noel G McElvaney
Patrick Geraghty
Shane J O'Neill
P2860
P304
31736-31744
P356
10.1074/JBC.M803732200
P407
P577
2008-09-04T00:00:00Z