Differential requirement for the SAP-Fyn interaction during NK T cell development and function. - Wikidata - awgldk - TriplyDB

Differential requirement for the SAP-Fyn interaction during NK T cell development and function.

Differential requirement for the SAP-Fyn interaction during NK T cell development and function.

http://www.wikidata.org/entity/Q39953297

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Antitumor Responses of Invariant Natural Killer T Cells SLAM-family receptors: immune regulators with or without SAP-family adaptors.Invariant NKT cell development requires a full complement of functional CD3 zeta immunoreceptor tyrosine-based activation motifs Transcriptional control of invariant NKT cell development.Invariant natural killer T-cell neutralization is a possible novel therapy for human eosinophilic esophagitis.Fyn kinase is required for optimal humoral responses.Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1.Invariant natural killer T cells generated from human adult hematopoietic stem-progenitor cells are poly-functional.Making memory at birth: understanding the differentiation of natural killer T cells SAP is required for the development of innate phenotype in H2-M3--restricted Cd8(+) T cells.Connecting the dots: artificial antigen presenting cell-mediated modulation of natural killer T cells.The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation.DOCK8 is critical for the survival and function of NKT cells The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis.X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses.SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.SAP-Dependent and -Independent Regulation of Innate T Cell Development Involving SLAMF Receptors.X-linked lymphoproliferative syndrome: a genetic condition typified by the triad of infection, immunodeficiency and lymphoma.Severe Epstein-Barr virus infection in primary immunodeficiency and the normal host.SLAM-associated protein favors the development of iNKT2 over iNKT17 cells.Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells.Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity.Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity.The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression.Importance and mechanism of 'switch' function of SAP family adapters.Transfer of gene-corrected T cells corrects humoral and cytotoxic defects in patients with X-linked lymphoproliferative disease.

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Differential requirement for the SAP-Fyn interaction during NK T cell development and function.

http://www.wikidata.org/entity/Q39953297

description

2008 nî lūn-bûn

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

Differential requirement for t ...... cell development and function.

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Differential requirement for t ...... cell development and function.

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type

label

Differential requirement for t ...... cell development and function.

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Differential requirement for t ...... cell development and function.

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Differential requirement for t ...... cell development and function.

@en

Differential requirement for t ...... cell development and function.

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JIMMUNOL.181.4.2311

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Journal of Immunology

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Differential requirement for t ...... cell development and function.

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André Veillette

http://www.w3.org/2001/XMLSchema#string

Dominique Davidson

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Gary A Koretzky

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Hamid Bassiri

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Jennifer Rothman

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Kim E Nichols

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Marisa Juntilla

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Priti Ojha

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Selene Nunez-Cruz

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W C Janice Yeo

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P2860

SAP couples Fyn to SLAM immune receptors

X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells

Defective NK cell activation in X-linked lymphoproliferative disease

Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development

Production of high-titer helper-free retroviruses by transient transfection

SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9.

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation.

Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny

Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.

The regulatory role of Valpha14 NKT cells in innate and acquired immune response.

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