Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.
about
Multiple Drug Transport Pathways through Human P-Glycoprotein.Intragenic suppressing mutations correct the folding and intracellular traffic of misfolded mutants of Yor1p, a eukaryotic drug transporter.Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface.What can naturally occurring mutations tell us about Ca(v)1.x channel function?Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch.Identification of residues in the drug translocation pathway of the human multidrug resistance P-glycoprotein by arginine mutagenesisLocking intracellular helices 2 and 3 together inactivates human P-glycoprotein.Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1)A promiscuous conformational switch in the secondary multidrug transporter MdfA.Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania.Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein.Targeted Next-Generation Sequencing for Comprehensive Genetic Profiling of Pharmacogenes.Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1.
P2860
Q27301793-773B603F-5D33-48A3-B7DC-355FF3DB8366Q34298963-6E3E81F2-68E7-402C-9039-4AE0210DC82DQ37012424-82F6BB1A-9809-4142-82A5-0D5AB5E11FF5Q37209113-01DD7BD6-19E0-401E-991D-4F3DFDD18FE3Q37653308-1B95266B-A5D3-43CF-A6E4-DE68FA0C2DAEQ39828462-3BB5739A-CB0A-4C8B-B976-0B5429664BA5Q41848364-9CB5FE3F-ACDA-4EA0-A9D3-A1B2A25749FCQ42085052-5B419CEC-304F-4E4F-9E2F-5BE08730B043Q42661799-F5CC438C-4A13-4C07-9A07-F41FD6FC019AQ42849844-226AB783-CABC-4DCF-AF3C-04BEB422D0B6Q43099273-EB7F8BFB-86AF-4D61-A7DD-291C8F192443Q51406902-B4054BFA-53BB-4993-996B-2BAAE5E3913AQ52976466-BE6EAD98-8782-4B43-A46F-9D26E4F1A95F
P2860
Arginines in the first transmembrane segment promote maturation of a P-glycoprotein processing mutant by hydrogen bond interactions with tyrosines in transmembrane segment 11.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
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2008年學術文章
@zh-hant
name
Arginines in the first transme ...... s in transmembrane segment 11.
@en
Arginines in the first transme ...... s in transmembrane segment 11.
@nl
type
label
Arginines in the first transme ...... s in transmembrane segment 11.
@en
Arginines in the first transme ...... s in transmembrane segment 11.
@nl
prefLabel
Arginines in the first transme ...... s in transmembrane segment 11.
@en
Arginines in the first transme ...... s in transmembrane segment 11.
@nl
P2093
P2860
P356
P1476
Arginines in the first transme ...... s in transmembrane segment 11.
@en
P2093
David M Clarke
M Claire Bartlett
P2860
P304
24860-24870
P356
10.1074/JBC.M803351200
P407
P577
2008-07-02T00:00:00Z