The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.
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Complement in age-related macular degeneration: a focus on functionThe complotype: dictating risk for inflammation and infectionA humanized antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factorsGenetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degenerationGenetics and complement in atypical HUS.Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities.Factors determining penetrance in familial atypical haemolytic uraemic syndrome.The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency.A haplotype in CFH family genes confers high risk of rare glomerular nephropathies.Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.Complement control protein factor H: the good, the bad, and the inadequate.Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration.Complement system in pathogenesis of AMD: dual player in degeneration and protection of retinal tissue.Characterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN.The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical applicationComplement factor B polymorphism 32W protects against age-related macular degeneration.Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease riskDense deposit disease.Allelic variants of complement genes associated with dense deposit disease.Copy number variation in the complement factor H-related genes and age-related macular degenerationFunctional analysis of a complement polymorphism (rs17611) associated with rheumatoid arthritisComplement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis.Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus.Complement factor H Val62Ile variant and risk of age-related macular degeneration: a meta-analysis.Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulationInsights into the Effects of Complement Factor H on the Assembly and Decay of the Alternative Pathway C3 Proconvertase and C3 Convertase.Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortiaGenetic control of the alternative pathway of complement in humans and age-related macular degenerationCFH haplotypes and ARMS2, C2, C3, and CFB alleles show association with susceptibility to age-related macular degeneration in Mexicans.C3 glomerulopathy: a new classification.How novel structures inform understanding of complement function.A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH-related proteins 1-5 in human plasma.The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement.Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation.A Novel Complotype Combination Associates with Age-Related Macular Degeneration and High Complement Activation Levels in vivo.Genetic modifier loci of mouse Mfrp(rd6) identified by quantitative trait locus analysis.
P2860
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P2860
The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
The disease-protective complem ...... nd enhanced cofactor activity.
@en
The disease-protective complem ...... nd enhanced cofactor activity.
@nl
type
label
The disease-protective complem ...... nd enhanced cofactor activity.
@en
The disease-protective complem ...... nd enhanced cofactor activity.
@nl
prefLabel
The disease-protective complem ...... nd enhanced cofactor activity.
@en
The disease-protective complem ...... nd enhanced cofactor activity.
@nl
P2093
P2860
P356
P1476
The disease-protective complem ...... nd enhanced cofactor activity.
@en
P2093
B Paul Morgan
Claire L Harris
Rubén Martínez-Barricarte
Santiago Rodríguez de Córdoba
Tamara Montes
P2860
P304
P356
10.1093/HMG/DDP289
P577
2009-06-23T00:00:00Z