A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation.

A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation.

Item
http://www.wikidata.org/entity/Q39972794
Bisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channelStructure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closingChaperone-mediated native folding of a β-scorpion toxin in the periplasm of Escherichia coliNetwork topology of NaV1.7 mutations in sodium channel-related painful disorders.Single amino acid deletion in transmembrane segment D4S6 of sodium channel Scn8a (Nav1.6) in a mouse mutant with a chronic movement disorder.Evolutionarily conserved intracellular gate of voltage-dependent sodium channels.Translational pain research: Lessons from genetics and genomics.A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel.Molecular architecture of a sodium channel S6 helix: radial tuning of the voltage-gated sodium channel 1.7 activation gateStructural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel.Erythromelalgia mutation Q875E Stabilizes the activated state of sodium channel Nav1.7.Can robots patch-clamp as well as humans? Characterization of a novel sodium channel mutation.Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation.
P2860

A pore-blocking hydrophobic motif at the cytoplasmic aperture of the closed-state Nav1.7 channel is disrupted by the erythromelalgia-associated F1449V mutation.

Item
http://www.wikidata.org/entity/Q39972794
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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name
A pore-blocking hydrophobic mo ...... ia-associated F1449V mutation.
@en
A pore-blocking hydrophobic mo ...... ia-associated F1449V mutation.
@nl
type
label
A pore-blocking hydrophobic mo ...... ia-associated F1449V mutation.
@en
A pore-blocking hydrophobic mo ...... ia-associated F1449V mutation.
@nl
prefLabel
A pore-blocking hydrophobic mo ...... ia-associated F1449V mutation.
@en
A pore-blocking hydrophobic mo ...... ia-associated F1449V mutation.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
A pore-blocking hydrophobic mo ...... gia-associated F1449V mutation
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932