Modulation of Lck function through multisite docking to T cell-specific adapter protein.
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Distinct Mechanisms Regulate Lck Spatial Organization in Activated T Cells.T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells.VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd.T cell specific adapter protein (TSAd) interacts with Tec kinase ITK to promote CXCL12 induced migration of human and murine T cells.Selective phosphorylation of the Dlg1AB variant is critical for TCR-induced p38 activation and induction of proinflammatory cytokines in CD8+ T cells.Reduced MCMV Δm157 viral clearance in the absence of TSAd.SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.Variants in the Signaling Protein TSAd are Associated with Susceptibility to Ovarian Cancer in BRCA1/2 Negative High Risk Families.A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells.A PLC-γ1 Feedback Pathway Regulates Lck Substrate Phosphorylation at the T-Cell Receptor and SLP-76 Complex.The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192.How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism.Expression of the T cell-specific adapter protein in human tissues.CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein.Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd
P2860
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P2860
Modulation of Lck function through multisite docking to T cell-specific adapter protein.
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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2008年学术文章
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2008年学术文章
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name
Modulation of Lck function through multisite docking to T cell-specific adapter protein.
@en
Modulation of Lck function through multisite docking to T cell-specific adapter protein.
@nl
type
label
Modulation of Lck function through multisite docking to T cell-specific adapter protein.
@en
Modulation of Lck function through multisite docking to T cell-specific adapter protein.
@nl
prefLabel
Modulation of Lck function through multisite docking to T cell-specific adapter protein.
@en
Modulation of Lck function through multisite docking to T cell-specific adapter protein.
@nl
P2093
P2860
P356
P1476
Modulation of Lck function through multisite docking to T cell-specific adapter protein.
@en
P2093
Burkhard Fleckenstein
Marit Jørgensen
Stine Granum
Thorny Cesilie Bie Andersen
Tone Berge
Vibeke Sundvold-Gjerstad
P2860
P304
21909-21919
P356
10.1074/JBC.M800871200
P407
P577
2008-06-09T00:00:00Z