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A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivoAbnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastasesThe secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiationAnnexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradationThe proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modificationsThe proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furinThe cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLRAnnexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levelsFurin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytesFunctional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoformVACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5Gene structure and chromosomal localization of plasma kallikreinBeta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furinThe metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)The isoforms of proprotein convertase PC5 are sorted to different subcellular compartmentsChloroquine is a potent inhibitor of SARS coronavirus infection and spread.PCSK9: a key modulator of cardiovascular healthRole of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipaseCellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammalsMutations in PCSK9 cause autosomal dominant hypercholesterolemiaThe proprotein convertases and their implication in sterol and/or lipid metabolismLipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptorThe production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in manPartial amino acid sequence of a human seminal plasma peptide with inhibin-like activityChromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and humanComparative functional role of PC7 and furin in the processing of the HIV envelope glycoprotein gp160In vivo evidence that furin from hepatocytes inactivates PCSK9Impaired fertility in mice deficient for the testicular germ-cell protease PC4Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturationRegulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertaseEndoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signalingImmunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brainImmunohistochemical distribution of the prohormone convertase PC5-A in rat brainTranslational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous systemEndoproteolytic processing of integrin pro-α subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7APOE p.Leu167del mutation in familial hypercholesterolemia.Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.
P50
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hulumtues
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Nabil G Seidah
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Nabil G Seidah
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Nabil G Seidah
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Nabil G Seidah
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Nabil G Seidah
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P1006
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P1006
P1053
I-3596-2013
P106
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0000 0000 1275 1793
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nb2011024288
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0000-0001-6503-9342
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lccn-nb2011024288