The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

Item
http://www.wikidata.org/entity/Q39983039
The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events.The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding RegionsThe deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function.How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization.The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.Ubiquitination: Added complexity in Ras and Rho family GTPase function.Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.USP17 is required for clathrin mediated endocytosis of epidermal growth factor receptor.Functional specificity of ras isoforms: so similar but so different.A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17.USP17 is upregulated in osteosarcoma and promotes cell proliferation, metastasis, and epithelial-mesenchymal transition through stabilizing SMAD4.
P2860

The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.

Item
http://www.wikidata.org/entity/Q39983039
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The deubiquitinating enzyme US ...... n but leaves K-Ras unaffected.
@en
The deubiquitinating enzyme US ...... n but leaves K-Ras unaffected.
@nl
type
label
The deubiquitinating enzyme US ...... n but leaves K-Ras unaffected.
@en
The deubiquitinating enzyme US ...... n but leaves K-Ras unaffected.
@nl
prefLabel
The deubiquitinating enzyme US ...... n but leaves K-Ras unaffected.
@en
The deubiquitinating enzyme US ...... n but leaves K-Ras unaffected.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932
P356
P1433
P1476
The deubiquitinating enzyme US ...... n but leaves K-Ras unaffected.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P932