Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo.
about
The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathiesClinical activity of patupilone in patients with pretreated advanced/metastatic colon cancer: results of a phase I dose escalation trial.Cell death signaling and anticancer therapyDifferentiating between models of epothilone binding to microtubules using tubulin mutagenesis, cytotoxicity, and molecular modelingThe microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasionTreatment of neuroblastoma and rhabdomyosarcoma using RGD-modified liposomal formulations of patupilone (EPO906).Tubulin-β-III overexpression by uterine serous carcinomas is a marker for poor overall survival after platinum/taxane chemotherapy and sensitivity to epothilones.Microtubule stabilising agents for cancer chemotherapy.The epothilones: how pharmacology relates to clinical utility.Tubulin targets in the pathobiology and therapy of glioblastoma multiforme. I. Class III beta-tubulin.Phase II trial of patupilone in patients with brain metastases from breast cancer.Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies.Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.Continuous low plasma concentrations of everolimus provides equivalent efficacy to oral daily dosing in mouse xenograft models of human cancer.Can taxanes provide benefit in patients with CNS tumors and in pediatric patients with tumors? An update on the preclinical development of cabazitaxel.Use of epothilone B (patupilone) in refractory lymphoma and advanced solid tumors in dogs.MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications.Pharmacokinetics and antitumor activity of patupilone combined with midazolam or omeprazole in patients with advanced cancer.Metabolism of patupilone in patients with advanced solid tumor malignancies.Multicenter phase 2 study of patupilone for recurrent or progressive brain metastases from non-small cell lung cancer.Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions.Patupilone (epothilone B) for recurrent glioblastoma: clinical outcome and translational analysis of a single-institution phase I/II trial.Epothilone B Speeds Corneal Nerve Regrowth and Functional Recovery through Microtubule Stabilization and Increased Nerve Beading.Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).Natural products: a hope for glioblastoma patients.
P2860
Q34587678-AF6EE747-329B-4A9B-8E2B-4BFDB198052DQ35623301-67433350-CB8B-405C-B6E1-3048F8E45441Q35972102-E59F9012-E833-4226-8B61-77533FC6BA3CQ36452372-3926701B-2801-4325-86A3-3EAF8A2390F8Q36866903-AC38AF9A-C00C-4A39-8F25-A45A07A4E495Q36957962-ECA9311C-1E6B-486A-A4FD-154EA2103D7AQ36980135-20D72B52-8BCF-4770-99F8-BED69FAD2D7EQ37481355-6B4ED43A-613A-4621-A42D-11CF2CB6B0BEQ37543912-964C6946-CD6D-4091-8480-AE16D52A226CQ37570220-134683AF-5309-4E71-BB4C-F947F9D197B2Q37641250-41258012-5B3A-41A3-A5BD-6D1B153BD278Q37841631-44ADD238-F3DF-4DE0-AC74-410ED6396E49Q38047388-40DAE9F6-EF5D-4023-A137-971FB67E1B3EQ38695683-244BBB60-A9E1-4D30-B8C4-CDBBF9AD88FCQ39131399-54FB5C60-4FCB-4CE7-8708-DCD586237E03Q39233661-113D47ED-0244-4D41-B74A-864FFDE0DFE5Q39780360-FBA51CD7-DA35-4101-9A2E-0CB7E39382F2Q39979640-27BBD1E7-0F81-4F8A-9E8F-A767DA4D1463Q40058701-B0046290-244B-4D78-9A5B-32AF780CD9FDQ40308252-D32A8E57-D530-42BF-8B99-4301AAB5A96EQ43424784-D27C8DFF-A67A-4CF9-A792-2ECF48AF2FFCQ48476827-CF609B87-5A3C-472F-B474-F1945431F960Q49483504-F1150B83-E0D2-4156-A93C-25909ED4DBE0Q51569908-554EA53F-8F25-443C-997D-16420B78A3E5Q55445418-787940CC-4EEA-4CAE-BA56-5F16C4CE6920
P2860
Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Pharmacokinetic profile of the ...... ther MTS in vitro and in vivo.
@en
type
label
Pharmacokinetic profile of the ...... ther MTS in vitro and in vivo.
@en
prefLabel
Pharmacokinetic profile of the ...... ther MTS in vitro and in vivo.
@en
P2093
P1476
Pharmacokinetic profile of the ...... ther MTS in vitro and in vivo.
@en
P2093
Andreas Floersheimer
Joseph Brueggen
Markus Wartmann
Michel Maira
Paul M J McSheehy
Peter R Allegrini
Terence O'Reilly
P2888
P304
P356
10.1007/S00280-008-0695-9
P577
2008-02-27T00:00:00Z
P6179
1041421114