Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association.
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The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signalingPKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-cateninDevelopment of a high-throughput assay for identifying inhibitors of TBK1 and IKKεVaricella-zoster virus immediate-early protein ORF61 abrogates the IRF3-mediated innate immune response through degradation of activated IRF3PLP2 of mouse hepatitis virus A59 (MHV-A59) targets TBK1 to negatively regulate cellular type I interferon signaling pathway.Requirement of NOX2 and reactive oxygen species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression.AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300.Structural insights into interferon regulatory factor activation.Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling.Identification of a novel in vivo virus-targeted phosphorylation site in interferon regulatory factor-3 (IRF3)Varicella-zoster virus immediate-early protein 62 blocks interferon regulatory factor 3 (IRF3) phosphorylation at key serine residues: a novel mechanism of IRF3 inhibition among herpesvirusesProteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunityUnabated adenovirus replication following activation of the cGAS/STING-dependent antiviral response in human cells.Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activationFunctionally distinct effects of the C-terminal regions of IKKε and TBK1 on type I IFN productionHSPD1 interacts with IRF3 to facilitate interferon-beta induction.Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression.Epstein-Barr virus BGLF4 kinase suppresses the interferon regulatory factor 3 signaling pathwayMAVS self-association mediates antiviral innate immune signalingAdenovirus induction of IRF3 occurs through a binary trigger targeting Jun N-terminal kinase and TBK1 kinase cascades and type I interferon autocrine signaling.The IKK Kinases: Operators of Antiviral Signaling.A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3.Fine-Tuning of the RIG-I-Like Receptor/Interferon Regulatory Factor 3-Dependent Antiviral Innate Immune Response by the Glycogen Synthase Kinase 3/β-Catenin PathwaySustained activation of interferon regulatory factor 3 during infection by paramyxoviruses requires MDA5.Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade.Endoplasmic reticulum stress regulates the innate immunity critical transcription factor IRF3.IRF3 inhibition by rotavirus NSP1 is host cell and virus strain dependent but independent of NSP1 proteasomal degradation.Differential modification of interferon regulatory factor 3 following virus particle entry.The TAK1-JNK cascade is required for IRF3 function in the innate immune response.Murine coronavirus delays expression of a subset of interferon-stimulated genesDUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection.Endoplasmic Reticulum Transmembrane Proteins ZDHHC1 and STING Both Act as Direct Adaptors for IRF3 Activation in Teleost.Glycogen synthase kinase 3 negatively regulates IFN regulatory factor 3 transactivation through phosphorylation at its linker region.
P2860
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P2860
Phosphorylation of IRF-3 on Ser 339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Phosphorylation of IRF-3 on Se ...... erization and CBP association.
@en
type
label
Phosphorylation of IRF-3 on Se ...... erization and CBP association.
@en
prefLabel
Phosphorylation of IRF-3 on Se ...... erization and CBP association.
@en
P2093
P2860
P356
P1433
P1476
Phosphorylation of IRF-3 on Se ...... erization and CBP association.
@en
P2093
Annie Bibeau-Poirier
Eric Bonneil
Jean-François Clément
Marc J Servant
Nathalie Grandvaux
Pierre Thibault
Simon-Pierre Gravel
Sylvain Meloche
P2860
P304
P356
10.1128/JVI.02526-07
P407
P577
2008-02-13T00:00:00Z