Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron.
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Dual role for mitogen-activated protein kinase (Erk) in insulin-dependent regulation of Fra-1 (fos-related antigen-1) transcription and phosphorylationThe estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctionsDistinct roles of Jun : Fos and Jun : ATF dimers in oncogenesisFOSL1 controls the assembly of endothelial cells into capillary tubes by direct repression of αv and β3 integrin transcriptionNeoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene productMultiple cis-elements mediate the transcriptional activation of human fra-1 by 12-O-tetradecanoylphorbol-13-acetate in bronchial epithelial cellsSmall molecule inhibitors targeting activator protein 1 (AP-1).Ligand-specific sequential regulation of transcription factors for differentiation of MCF-7 cellsAn association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy.Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells.Emerging roles of ATF2 and the dynamic AP1 network in cancer.The binding of a Fos/Jun heterodimer can completely disrupt the structure of a nucleosomeRetinoblastoma protein and MyoD function together to effect the repression of Fra-1 and in turn cyclin D1 during terminal cell cycle arrest associated with myogenesis.An extracellular signal-regulated kinase 1- and 2-dependent program of chromatin trafficking of c-Fos and Fra-1 is required for cyclin D1 expression during cell cycle reentry.Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently.A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration.FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.Epigenetics in high-grade astrocytomas: opportunities for prevention and detection of brain tumors.FRA-1 as a driver of tumour heterogeneity: a nexus between oncogenes and embryonic signalling pathways in cancer.JunD-mediated repression of GADD45α and γ regulates escape from cell death in prostate cancerGlobal expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cePromoter-level expression clustering identifies time development of transcriptional regulatory cascades initiated by ErbB receptors in breast cancer cells.Visualization of Fra-1/AP-1 activation during LPS-induced inflammatory lung injury using fluorescence optical imaging.Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion.DT-diaphorase activity in NSCLC and SCLC cell lines: a role for fos/jun regulationActin cytoskeletal mediators of motility and invasion amplified and overexpressed in head and neck cancer.Synergistic activation of human involucrin gene expression by Fra-1 and p300--evidence for the presence of a multiprotein complex.Cooperation of protein kinase A and Ras/ERK signaling pathways is required for AP-1-mediated activation of fibroblast growth factor-inducible response element (FiRE).Transactivation and expression patterns of Jun and Fos/AP-1 super-family proteins in human oral cancer.Identification of nuclear orphan receptors as regulators of expression of a neurotransmitter receptor gene.Activated MEK stimulates expression of AP-1 components independently of phosphatidylinositol 3-kinase (PI3-kinase) but requires a PI3-kinase signal To stimulate DNA synthesis.The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation.Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL.Role of MSK1 in the malignant phenotype of Ras-transformed mouse fibroblasts.PMA up-regulates the transcription of Axl by AP-1 transcription factor binding to TRE sequences via the MAPK cascade in leukaemia cells.Heterodimerization with Fra-1 cooperates with the ERK pathway to stabilize c-Jun in response to the RAS oncoprotein.Accumulation of Fra-1 in ras-transformed cells depends on both transcriptional autoregulation and MEK-dependent posttranslational stabilizationAberrant expression of Fra-1 in estrogen receptor-negative breast cancers and suppression of their propagation in vivo by ascochlorin, an antibiotic that inhibits cellular activator protein-1 activity.Ubiquitin-independent proteasomal degradation of Fra-1 is antagonized by Erk1/2 pathway-mediated phosphorylation of a unique C-terminal destabilizer.
P2860
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P2860
Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Transcriptional activation of ...... sequences in the first intron.
@en
type
label
Transcriptional activation of ...... sequences in the first intron.
@en
prefLabel
Transcriptional activation of ...... sequences in the first intron.
@en
P2093
P2860
P356
P1476
Transcriptional activation of ...... sequences in the first intron.
@en
P2093
Braselmann S
Busslinger M
Graninger P
Wrighton C
P2860
P304
P356
10.1128/MCB.15.7.3748
P407
P577
1995-07-01T00:00:00Z