E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis.
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p53 regulation of G(2) checkpoint is retinoblastoma protein dependentETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domainCDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phaseSelection of novel mediators of E2F1-induced apoptosis through retroviral expression of an antisense cDNA libraryTranscriptional control of stem cell fate by E2Fs and pocket proteinsA novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosisInvolvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death.BAD detects coincidence of G2/M phase and growth factor deprivation to regulate apoptosis.The role of c-myc in cellular growth control.Death and destruction of activated T lymphocytes.Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors.Identification of positive and negative regulatory regions involved in regulating expression of the human cytomegalovirus UL94 late promoter: role of IE2-86 and cellular p53 in mediating negative regulatory function.Induction of the cellular E2F-1 promoter by the adenovirus E4-6/7 protein.The retinoblastoma gene family in differentiation and development.Cell cycle regulators: mechanisms and their role in aetiology, prognosis, and treatment of cancer.p53 facilitates pRb cleavage in IL-3-deprived cells: novel pro-apoptotic activity of p53.The p53 tumour suppressor protein.Activation of cell cycle arrest and apoptosis by the proto-oncogene Pim-2.Regulation of E2F1-dependent gene transcription and apoptosis by the ETS-related transcription factor GABPgamma1.Mutant mouse models reveal the relative roles of E2F1 and E2F3 in vivo.E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis.E2F1 pathways to apoptosis.Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program.The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter.Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation.Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agentsE2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis.E2F1 death pathways as targets for cancer therapyModulation of the E2F1-driven cancer cell fate by the DNA damage response machinery and potential novel E2F1 targets in osteosarcomasAntisense MDM2 enhances E2F1-induced apoptosis and the combination sensitizes androgen-sensitive [corrected] and androgen-insensitive [corrected] prostate cancer cells to radiation.Targeting AAC-11 in cancer therapy.Gene expression changes in response to E2F1 activation.Direct repression of the Mcl-1 promoter by E2F1.Identification and characterization of novel isoforms of human DP-1: DP-1{alpha} regulates the transcriptional activity of E2F1 as well as cell cycle progression in a dominant-negative manner.The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation.Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc.E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short).Genetic and epigenetic alterations of RB2/p130 tumor suppressor gene in human sporadic retinoblastoma: implications for pathogenesis and therapeutic approach.E2F1 promotes cytokine mediated cell survival via a mechanism that is separable from its cell cycle regulatory effects.E2F1 selects tumour cells for both life and death.
P2860
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P2860
E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis.
@en
type
label
E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis.
@en
prefLabel
E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis.
@en
P2093
P2860
P356
P1476
E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis.
@en
P2093
G Zambetti
J L Cleveland
S W Hiebert
P2860
P304
P356
10.1128/MCB.15.12.6864
P407
P577
1995-12-01T00:00:00Z