Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc. - Wikidata - awgldk - TriplyDB

Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc.

Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc.

http://www.wikidata.org/entity/Q40020332

about

TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1 Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death Sumoylation of eIF4E activates mRNA translation Cloning and characterization of 4EHP, a novel mammalian eIF4E-related cap-binding protein Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon?4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure.Cloning and characterization of human eIF4E genes.Molecular mechanisms of cell proliferation induced by low power laser irradiation Involvement of ribosomal proteins in regulating cell growth and apoptosis: translational modulation or recruitment for extraribosomal activity?The lymphocytic choriomeningitis virus RING protein Z associates with eukaryotic initiation factor 4E and selectively represses translation in a RING-dependent manner.Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cells Temsirolimus in the treatment of relapsed or refractory mantle cell lymphoma.Eukaryotic initiation factor 4F: a vulnerability of tumor cells.Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency.The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro.Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins.Targeting the eIF4F translation initiation complex: a critical nexus for cancer development eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells.eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling.Rapid turnover of mcl-1 couples translation to cell survival and apoptosis.Translational control in T lymphocytes.Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling.Initiation factor modifications in the preapoptotic phase.Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells.The eIF4E RNA regulon promotes the Akt signaling pathway.The oncogene eIF4E: using biochemical insights to target cancer.Stress and IGF-I differentially control cell fate through mammalian target of rapamycin (mTOR) and retinoblastoma protein (pRB)Impaired translational response and increased protein kinase PKR expression in T cells from lupus patients.Translation initiation: a critical signalling node in cancer.Cap and cap-binding proteins in the control of gene expression.Translational control of cell fate: from integration of environmental signals to breaching anticancer defense.Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond.Functional characterization of five eIF4E isoforms in Caenorhabditis elegans.

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P2860

Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc.

http://www.wikidata.org/entity/Q40020332

description

1996 nî lūn-bûn

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Translational control of progr ...... expressed or deregulated Myc.

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Translational control of progr ...... expressed or deregulated Myc.

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Translational control of progr ...... expressed or deregulated Myc.

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Molecular and Cellular Biology

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Translational control of progr ...... y expressed or deregulated Myc

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A T Tan

http://www.w3.org/2001/XMLSchema#string

I B Rosenwald

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J White

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L Chiang

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N Sonenberg

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V A Polunovsky

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P2860

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes

Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels

Induction of apoptosis in fibroblasts by c-myc protein

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

Platelet-derived growth factor induces apoptosis in growth-arrested murine fibroblasts

cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells.

Role of mesenchymal cell death in lung remodeling after injury.

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10.1128/MCB.16.11.6573

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11

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Peter B Bitterman

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14318619

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8887686

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231659

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