Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo.
about
A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free systemThe repressor DREAM acts as a transcriptional activator on Vitamin D and retinoic acid response elementsCharacterization of retinoic acid receptor-deficient keratinocytes1,25(OH)2vitamin D3 inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cellsIdentification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing HypercalcemiaDNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex.Fine-Tuning Reception in the Bone: PPARgamma and Company.Analysis of differential secondary effects of novel rexinoids: select rexinoid X receptor ligands demonstrate differentiated side effect profiles.The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.Retinoid X receptor:vitamin D3 receptor heterodimers promote stable preinitiation complex formation and direct 1,25-dihydroxyvitamin D3-dependent cell-free transcription.Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response.Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydroA central dinucleotide within vitamin D response elements modulates DNA binding and transactivation by the vitamin D receptor in cellular response to natural and synthetic ligands.A two-hit mechanism for vitamin D3-mediated transcriptional repression of the granulocyte-macrophage colony-stimulating factor gene: vitamin D receptor competes for DNA binding with NFAT1 and stabilizes c-Jun.1α,25-dihydroxyvitamin D3 modulates the hair-inductive capacity of dermal papilla cells: therapeutic potential for hair regeneration.1alpha,25-dihydroxyvitamin D3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-kappaB-mediated interleukin-8 gene expression.Dimerization with retinoid X receptors promotes nuclear localization and subnuclear targeting of vitamin D receptors.Inhibition of 1,25-dihydroxyvitamin D3-dependent transcription by synthetic LXXLL peptide antagonists that target the activation domains of the vitamin D and retinoid X receptors.1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects.Synthetic LXXLL peptide antagonize 1,25-dihydroxyvitamin D3-dependent transcription.Induction of nephrin gene expression by selective cooperation of the retinoic acid receptor and the vitamin D receptor.Retinoid X receptor (RXR) ligands activate the human 25-hydroxyvitamin D3-24-hydroxylase promoter via RXR heterodimer binding to two vitamin D-responsive elements and elicit additive effects with 1,25-dihydroxyvitamin D3.Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice.A novel gene expression analytics-based approach to structure aided design of rexinoids for development as next-generation cancer therapeutics1,25(OH)D suppresses proinflammatory responses by inhibiting Th1 cell differentiation and cytokine production through the JAK/STAT pathway
P2860
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P2860
Selective effects of ligands on vitamin D3 receptor- and retinoid X receptor-mediated gene activation in vivo.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Selective effects of ligands o ...... iated gene activation in vivo.
@en
type
label
Selective effects of ligands o ...... iated gene activation in vivo.
@en
prefLabel
Selective effects of ligands o ...... iated gene activation in vivo.
@en
P2860
P356
P1476
Selective effects of ligands o ...... iated gene activation in vivo.
@en
P2093
P2860
P304
P356
10.1128/MCB.16.3.1006
P407
P577
1996-03-01T00:00:00Z