Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.
about
The ankyrin repeat as molecular architecture for protein recognitionHypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRbStructure of the cyclin-dependent kinase inhibitor p19Ink4dFunctional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information.Interpreting missense variants: comparing computational methods in human disease genes CDKN2A, MLH1, MSH2, MECP2, and tyrosinase (TYR).Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients.A single genetic origin for the G101W CDKN2A mutation in 20 melanoma-prone familiesA common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families.CDKN2A and CDK4 mutation analysis in Italian melanoma-prone families: functional characterization of a novel CDKN2A germ line mutationFamilial melanoma-associated mutations in p16 uncouple its tumor-suppressor functionsThe contribution of large genomic deletions at the CDKN2A locus to the burden of familial melanomaA comparison of CDKN2A mutation detection within the Melanoma Genetics Consortium (GenoMEL).Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early interventionAssessment of functional effects of unclassified genetic variants.Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors.CDKN2A unclassified variants in familial malignant melanoma: combining functional and computational approaches for their assessment.Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors.C-terminal domain of p16(INK4a) is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT-1080 fibrosarcoma cells.INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescencePredicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A.P18 is a tumor suppressor gene involved in human medullary thyroid carcinoma and pheochromocytoma development.The melanoma-associated 24 base pair duplication in p16INK4a is functionally impaired.Translation of p15.5INK4B, an N-terminally extended and fully active form of p15INK4B, is initiated from an upstream GUG codon.Functional reassessment of P16 variants using a transfection-based assay.Role of the cyclin-dependent kinase inhibitor CDKN2A in familial melanoma.Sherloc: a comprehensive refinement of the ACMG-AMP variant classification criteria.Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization.Expression of p16INK4A variants in senescent human fibroblasts independent of protein phosphorylation.Features of replicative senescence induced by direct addition of antennapedia-p16INK4A fusion protein to human diploid fibroblasts.CDKN2A mutations in melanoma families from Uruguay.Germline Mutations of the CDKN2 Gene in UK Melanoma FamiliesSporadic multiple primary melanoma cases:CDKN2Agermline mutations with a founder effectWild type and melanoma-associated mutant p16INK4aproteins do not oligomerize in vivo
P2860
Q24646394-9517C419-AC20-4532-A870-CE2A041678DAQ24656289-F2789AA3-E1BD-4949-8772-C94CE22789CBQ27746702-248251CB-6490-48DF-9650-C85517F57B4BQ30322978-C25CC23B-FE1F-4371-ABA0-28349BC54AA7Q30360539-03221D20-9C34-46AD-BAE8-AFD662B67C88Q30375327-EA74FFD8-0777-418D-9A7D-7EB8D22FAC66Q34142079-286C2B14-744A-4A0A-B16F-7DD5EC2D9A9BQ36623623-DEDE0935-2A95-40C4-980E-7FC441A96CEFQ36643400-907797C1-0879-458D-9131-3D53037326B5Q36674934-8E69B671-1F7D-41CC-A98F-9424FBF92ECBQ36785968-78591AC7-0C59-424B-B83E-E8192DBB3D15Q36808635-E37004ED-6E6B-4833-B209-0D83BAFF4601Q36984855-EFA59D88-C791-45E2-8303-BDC649AC9154Q37308298-A82ECEEC-8D3A-446C-83DD-046CF93FE54FQ38567353-D1955286-BB14-462A-97FC-4796695FB0D7Q39012719-0C8EBD3B-FD70-4B74-A972-94D5F7ABD8CAQ39444740-D48E7F41-85AC-4938-B0E5-0442F06F8AE7Q39635357-77E22EC1-EF29-4A4C-BD22-8ECA406AEDF4Q39647398-8BAC318C-7CEE-4CD1-9A99-5DD70ABE2B19Q39722414-583D2DC1-2F4D-4241-9906-540CD1E76F80Q39926491-61B493CC-6609-4E09-B745-491A1B09D14CQ40411801-9C3E6CAE-8F7C-4BDC-841B-EF42B3ED5089Q40887241-F9407413-2CDE-4867-B8BB-27650FBE522AQ40944770-4E7C2FFF-5DED-4DA1-A416-475D962E8D47Q41710434-B12A0D2A-5A3F-4482-9A4E-2475C995E521Q42270133-55D84F82-5931-46CB-B16D-3F3D52541FB2Q42628813-41E9F28F-05AD-4B33-9EDC-DCC50E383853Q45237079-CD6514CB-4D80-47B3-AFFE-C287693516C6Q48025794-30010A46-7D2E-48C0-9580-E2B249409152Q54739221-E0E26DD7-6FEE-4314-8201-1C90B265173BQ56438333-56412234-31AB-443E-8ADA-B688E52374ABQ56893701-F82AEE5D-3FE2-4A6B-9676-9FCA4B24C8ABQ58024836-AF7CBFDE-F0ED-46B5-9FBC-B0183A4A8A9F
P2860
Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.
@en
type
label
Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.
@en
prefLabel
Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.
@en
P2860
P356
P1476
Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.
@en
P2093
P2860
P304
P356
10.1128/MCB.16.7.3844
P407
P577
1996-07-01T00:00:00Z