Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors.
about
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanismsReversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1bCrystal structure of human CDK4 in complex with a D-type cyclinExpression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer.Targeting CDK4 and CDK6: From Discovery to TherapyDistinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitorscdk6 can shorten G(1) phase dependent upon the N-terminal INK4 interaction domainAn important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferationTumor suppressors and cell-cycle proteins in lung cancerLysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradationThe proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progressionHsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinaseAltered regulation of cell cycle machinery involved in interleukin-1-induced G(1) and G(2) phase growth arrest of A375S2 human melanoma cells.Leishmania major MPK7 protein kinase activity inhibits intracellular growth of the pathogenic amastigote stage.Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiationDevelopmental defects and tumor predisposition in Rb mutant mice.Regulation of the G1 phase of the mammalian cell cycle.Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.INK4d-deficient mice are fertile despite testicular atrophyCooperation of p27(Kip1) and p18(INK4c) in progestin-mediated cell cycle arrest in T-47D breast cancer cells.The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissuesAnalysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1).Cell cycle checkpoints and their inactivation in human cancer.Paradigms of growth control: relation to Cdk activation.Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability.Characterization of tumor suppressive function of cornulin in esophageal squamous cell carcinoma.p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.Regulation of CDK4Analysis of cell cycle regulator proteins in non-small cell lung cancer.p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2, and H19Transgenic expression of cyclin-dependent kinase 4 results in epidermal hyperplasia, hypertrophy, and severe dermal fibrosis.Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation.Reprogramming leukemic cells to terminal differentiation by inhibiting specific cyclin-dependent kinases in G1.Role of cell-cycle regulators in lung cancer.Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activityEffects of retinoic acid on proliferation, phenotype and expression of cyclin-dependent kinase inhibitors in TGF-beta1-stimulated rat hepatic stellate cellsCyclin-dependent kinase inhibitors in yeast, animals, and plants: a functional comparison.Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts
P2860
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P2860
Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Cyclin D-CDK subunit arrangeme ...... INK4 and p21 class inhibitors.
@en
Cyclin D-CDK subunit arrangeme ...... INK4 and p21 class inhibitors.
@nl
type
label
Cyclin D-CDK subunit arrangeme ...... INK4 and p21 class inhibitors.
@en
Cyclin D-CDK subunit arrangeme ...... INK4 and p21 class inhibitors.
@nl
prefLabel
Cyclin D-CDK subunit arrangeme ...... INK4 and p21 class inhibitors.
@en
Cyclin D-CDK subunit arrangeme ...... INK4 and p21 class inhibitors.
@nl
P2093
P2860
P356
P1476
Cyclin D-CDK subunit arrangeme ...... INK4 and p21 class inhibitors.
@en
P2093
P2860
P304
P356
10.1128/MCB.19.3.1775
P407
P577
1999-03-01T00:00:00Z