Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways.
about
Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growthPAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodiaMSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblastsSeparation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutantThe small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreadingThe TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodelingMyotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganizationCDC42 and FGD1 cause distinct signaling and transforming activities.MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathwaysStimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1.Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complexCritical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformationHIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathwayFRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophagesMyoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processesEndogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathwayPaxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling.Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivationP21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblastsThe evolutionary history of effectors downstream of Cdc42 and Rac.The Rac1 hypervariable region in targeting and signaling: a tail of many storiesRhoGTPases as key players in mammalian cell adaptation to microgravityRas uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosisAltered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoAThe formin/diaphanous-related protein, FHOS, interacts with Rac1 and activates transcription from the serum response element14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domainRac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerinRAS oncogenes: weaving a tumorigenic webPAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cellsActivation of G1 progression, JNK mitogen-activated protein kinase, and actin filament assembly by the exchange factor FGD1Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progressionCyclins: roles in mitogenic signaling and oncogenic transformationMicrotubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cellsLoss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targetingA Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in miceExtracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth.Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation
P2860
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P2860
Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Rac regulation of transformati ...... ple, PAK-independent pathways.
@en
type
label
Rac regulation of transformati ...... ple, PAK-independent pathways.
@en
prefLabel
Rac regulation of transformati ...... ple, PAK-independent pathways.
@en
P2093
P2860
P356
P1476
Rac regulation of transformati ...... ple, PAK-independent pathways.
@en
P2093
J K Westwick
L Van Aelst
Q T Lambert
R G Pestell
P2860
P304
P356
10.1128/MCB.17.3.1324
P407
P577
1997-03-01T00:00:00Z