A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice
about
Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalkModulation of actin dynamics by Rac1 to target cognitive functionApproaches of targeting Rho GTPases in cancer drug discoveryModulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosisNovel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPasesControl of developmental networks by Rac/Rho small GTPases: How cytoskeletal changes during embryogenesis are orchestratedThe Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.microRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma.Targeting Rho-GTPases in immune cell migration and inflammation.Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry.S-score: a scoring system for the identification and prioritization of predicted cancer genes.microRNA-195 inhibits cell proliferation in bladder cancer via inhibition of cell division control protein 42 homolog/signal transducer and activator of transcription-3 signaling.A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice.ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells.Deregulation of Rho GTPases in cancermiR-675-5p enhances tumorigenesis and metastasis of esophageal squamous cell carcinoma by targeting REPS2.A role for activated Cdc42 in glioblastoma multiforme invasion.Rho GTPases modulate malignant transformation of tumor cells.Direct Modulation of Small GTPase Activity and Function.Graf1 Controls the Growth of Human Parainfluenza Virus Type 2 through Inactivation of RhoA Signaling.Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells.The role of small GTPases of the Rho/Rac family in TGF-β-induced EMT and cell motility in cancer.Inhibition of invasion and metastasis of human liver cancer HCCLM3 cells by portulacerebroside A.Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864.Molecular pathways: targeting the kinase effectors of RHO-family GTPases.Discovery and characterization of small molecule Rac1 inhibitorsRac1 GTPase in pancreatic cancer.Rho GTPases as therapeutic targets in Alzheimer's disease.Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway.A High-Throughput Assay for Rho Guanine Nucleotide Exchange Factors Based on the Transcreener GDP Assay.Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.
P2860
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P2860
A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice
description
2013 nî lūn-bûn
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2013 թուականին հրատարակուած գիտական յօդուած
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2013 թվականին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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name
A Rac1/Cdc42 GTPase-specific s ...... and prolongs survival in mice
@ast
A Rac1/Cdc42 GTPase-specific s ...... and prolongs survival in mice
@en
A Rac1/Cdc42 GTPase-specific s ...... and prolongs survival in mice
@nl
type
label
A Rac1/Cdc42 GTPase-specific s ...... and prolongs survival in mice
@ast
A Rac1/Cdc42 GTPase-specific s ...... and prolongs survival in mice
@en
A Rac1/Cdc42 GTPase-specific s ...... and prolongs survival in mice
@nl
prefLabel
A Rac1/Cdc42 GTPase-specific s ...... and prolongs survival in mice
@ast
A Rac1/Cdc42 GTPase-specific s ...... and prolongs survival in mice
@en
A Rac1/Cdc42 GTPase-specific s ...... and prolongs survival in mice
@nl
P2860
P50
P3181
P1433
P1476
A Rac1/Cdc42 GTPase-specific s ...... and prolongs survival in mice
@en
P2093
Patrick Reichl
Seyedhossein Aharinejad
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0074924
P407
P577
2013-01-01T00:00:00Z