A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways.
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The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesisTyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or FynRequirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transportInsulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cellsv-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-Ras.A combined genetic and biochemical approach to mammalian signal transduction.The Ras-JNK pathway is involved in shear-induced gene expressionHuman adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signaling.Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36.Molecular mechanisms of metabolic regulation by insulin in Drosophila.Activation mechanisms of the urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor.Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs.Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytesCharacterization and properties of dominant-negative mutants of the ras-specific guanine nucleotide exchange factor CDC25(Mm).Cytoskeleton reorganization induces the urokinase-type plasminogen activator gene via the Ras/extracellular signal-regulated kinase (ERK) signaling pathway.Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases.Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway.Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor.Insulin and phorbol ester stimulate initiation factor eIF-4E phosphorylation by distinct pathways in Chinese hamster ovary cells overexpressing the insulin receptor.The insulin-dependent biosynthesis of GLUT1 and GLUT3 glucose transporters in L6 muscle cells is mediated by distinct pathways. Roles of p21ras and pp70 S6 kinase.Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin.Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance.Rapid activation of sodium-proton exchange and extracellular signal-regulated protein kinase in fibroblasts by G protein-coupled 5-HT1A receptor involves distinct signalling cascades.Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway.PI 3-kinase gamma and protein kinase C-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor.Activation and nuclear translocation of mitogen-activated protein kinases by polyomavirus middle-T or serum depend on phosphatidylinositol 3-kinase.Insulin-like growth factor-I receptor and insulin receptor association with a Src homology-2 domain-containing putative adapter.
P2860
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P2860
A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
A dominant-negative mutant of ...... nt insulin signaling pathways.
@en
type
label
A dominant-negative mutant of ...... nt insulin signaling pathways.
@en
prefLabel
A dominant-negative mutant of ...... nt insulin signaling pathways.
@en
P2093
P2860
P356
P1476
A dominant-negative mutant of ...... nt insulin signaling pathways.
@en
P2093
P2860
P304
P356
10.1128/MCB.15.1.379
P407
P577
1995-01-01T00:00:00Z